免疫活性细胞的表面抗原。3. B细胞和T细胞在免疫记忆中作用的体外研究。
Surface antigens of immunocompetent cells. 3. In vitro studies of the role of B and T cells in immunological memory.
作者信息
Mond J J, Takahashi T, Thorbecke G J
出版信息
J Exp Med. 1972 Oct 1;136(4):663-75. doi: 10.1084/jem.136.4.663.
Abstract
The effect of preincubation with anti-theta or anti-mouse immunoglobulin (Ig) and complement (C') on immune responsiveness of spleen cells from BALB/c mice immunized with sheep erythrocytes (SE) was investigated. Both treatments greatly depressed the remaining ability to produce a secondary response to SE in vitro. Normal BALB/c spleen cells were far less effective in reconstituting the responses of such depleted cell populations than were much smaller numbers of untreated immune spleen cells. Thymus-derived cell (T cell) memory appeared early after immunization and showed specificity for the immunizing antigens. Recombination of anti-Ig-treated with anti-theta-treated immune spleen cells resulted in virtually complete reconstitution of responsiveness. The presence of immunological memory in T cells and the nature of their surface receptors are discussed.
摘要
研究了用抗θ或抗小鼠免疫球蛋白（Ig）及补体（C'）进行预孵育对用绵羊红细胞（SE）免疫的BALB/c小鼠脾细胞免疫反应性的影响。两种处理均极大地降低了体外对SE产生二次反应的剩余能力。正常BALB/c脾细胞在重建此类耗尽细胞群体的反应方面远不如数量少得多的未处理免疫脾细胞有效。胸腺衍生细胞（T细胞）记忆在免疫后早期出现，并表现出对免疫抗原的特异性。用抗Ig处理的免疫脾细胞与用抗θ处理的免疫脾细胞重组，导致反应性几乎完全重建。文中讨论了T细胞中免疫记忆的存在及其表面受体的性质。
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本文引用的文献
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J Exp Med. 1970 Dec 1;132(6):1181-90. doi: 10.1084/jem.132.6.1181.
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Surface immunoglobulins on thymus and thymus-derived lymphoid cells.胸腺及胸腺衍生淋巴细胞上的表面免疫球蛋白
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Cell mediated immune reactions "in vitro". Reactivity of lymphocytes from animals sensitized to chicken erythrocytes, tuberculin or transplantation antigens.体外细胞介导的免疫反应。对鸡红细胞、结核菌素或移植抗原致敏的动物淋巴细胞的反应性。
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