Brown P C, Glynn L E
Immunology. 1969 Dec;17(6):943-53.
Immunological tolerance to synthetic polypeptides containing poly-L-proline has been induced in guinea-pigs by appropriate injections. The recovery from tolerance without further immunization has been followed by repeated skin testing. The tolerance involved both humoral antibody production and the development of delayed hypersensitivity. The results were interpreted on the basis of two hypotheses. (1) The avidity between antigen and antibody is a function of both the accuracy of fit and the extent over which the fitting takes place. (2) Antibody produced in animals showing partial tolerance differs from antibody in non-tolerant animals by a less perfect fit. Evidence is also presented that immunization with antigen in the presence of antibody to some only of its determinants favours an immune response to the remaining determinants.
通过适当注射，已在豚鼠中诱导出对含聚-L-脯氨酸的合成多肽的免疫耐受性。在未进一步免疫的情况下从耐受性中恢复后，进行了反复的皮肤试验。这种耐受性涉及体液抗体产生和迟发型超敏反应的发展。结果基于两个假说进行了解释。（1）抗原与抗体之间的亲和力是契合度准确性和契合发生程度的函数。（2）在表现出部分耐受性的动物中产生的抗体与非耐受性动物中的抗体不同，其契合度较差。还提供了证据表明，在仅针对其某些决定簇存在抗体的情况下用抗原进行免疫有利于对其余决定簇的免疫反应。
