一些与胶原蛋白相关的合成多肽的抗原性和耐受性。
Antigenicity and tolerance of some synthetic polypeptides related to collagen.
作者信息
Brown P C, Glynn L E
出版信息
Immunology. 1968 Oct;15(4):589-97.
Guinea-pigs immunized with poly-L-proline, poly-L-proline—glycine or poly-L-proline—glycine—acetyl-hydroxy-L-proline develop antibodies which appear to be exclusively directed against determinants composed of sequences of proline. (2) All three antigens also induce delayed hypersensitivity but the determinants involved include both glycine- and acetyl-hydroxyproline when the antigen is poly-proline—glycine—acetyl-hydroxyproline and glycine when the antigen is poly-proline—glycine. (3) The administration of either polyproline or poly-proline—glycine in incomplete adjuvant produces a state of tolerance as revealed by subsequent injection of the peptides with Freund's complete adjuvant. (4) Tolerance induced with poly-proline cannot be broken by immunization with poly-proline—glycine with regard to circulating antibody but is broken with regard to delayed hypersensitivity.
用聚-L-脯氨酸、聚-L-脯氨酸-甘氨酸或聚-L-脯氨酸-甘氨酸-乙酰羟基-L-脯氨酸免疫豚鼠后，会产生似乎仅针对由脯氨酸序列组成的决定簇的抗体。(2) 所有这三种抗原也会诱导迟发型超敏反应，但当抗原是聚脯氨酸-甘氨酸-乙酰羟基脯氨酸时，所涉及的决定簇包括甘氨酸和乙酰羟脯氨酸，而当抗原是聚脯氨酸-甘氨酸时，所涉及的决定簇包括甘氨酸。(3) 在不完全佐剂中给予聚脯氨酸或聚脯氨酸-甘氨酸会产生耐受状态，这可通过随后用弗氏完全佐剂注射这些肽来揭示。(4) 就循环抗体而言，用聚脯氨酸诱导的耐受不能被用聚脯氨酸-甘氨酸免疫打破，但就迟发型超敏反应而言可以被打破。
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