萘啶酸对枯草芽孢杆菌PBS2噬菌体感染的影响。
Effect of nalidixic acid on PBS2 bacteriophage infection of Bacillus subtilis.
作者信息
Price A R, Fogt S M
出版信息
J Virol. 1973 Aug;12(2):405-7. doi: 10.1128/JVI.12.2.405-407.1973.
Abstract
Infection of Bacillus subtilis by PBS2 phage, whose DNA contains uracil instead of thymine, is relatively unaffected by low concentrations of nalidixic acid which severely inhibit B. subtilis DNA synthesis. High concentrations of nalidixic acid do inhibit PBS2 DNA synthesis, but more severely reduce the burst size of PBS2 infections. Hydroxyurea blocks PBS2 DNA synthesis, preventing progeny phage production.
摘要
PBS2噬菌体感染枯草芽孢杆菌，其DNA含有尿嘧啶而非胸腺嘧啶，低浓度的萘啶酸对其感染影响相对较小，而萘啶酸会严重抑制枯草芽孢杆菌的DNA合成。高浓度的萘啶酸确实会抑制PBS2的DNA合成，但更严重地降低了PBS2感染的爆发量。羟基脲会阻断PBS2的DNA合成，阻止子代噬菌体的产生。
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本文引用的文献
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Effect of nalidixic acid on the growth of bacterial viruses.萘啶酸对细菌病毒生长的影响。
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Effect of nalidixic acid on deoxyribonucleic acid synthesis in bacteriophage SPO1-infected Bacillus subtilis.萘啶酸对噬菌体SPO1感染的枯草芽孢杆菌中脱氧核糖核酸合成的影响。
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