噬菌体PBS2诱导的含尿嘧啶DNA降解抑制作用。
Bacteriophage PBS2-induced inhibition of uracil-containing DNA degradation.
作者信息
Katz G E, Price A R, Pomerantz M J
出版信息
J Virol. 1976 Nov;20(2):535-8. doi: 10.1128/JVI.20.2.535-538.1976.
Abstract
Degradation of uracil-containing DNA by Bacillus subtilis extracts and its inhibition after infection by the uracil-containing DNA phage PBS2 have been investigated to resolve differences between the published reports of Tomita and Takahashi (1975) and Friedberg et al. (1975, 1976). The product of hydrolysis of PBS2 DNA, tritium labeled in its uracil and cytosine residues, is solely uracil and not deoxyuridine. The degrading activity is completely inhibited within 7 min after PBS2 infection, before any other known PBS2-induced protein is detectable. The production of the PBS2 inhibitor (a small, heat-stable protein) continues until 10 to 20 min postinfection.
摘要
为了解决富田和高桥（1975年）以及弗里德伯格等人（1975年、1976年）已发表报告之间的差异，对枯草芽孢杆菌提取物对含尿嘧啶DNA的降解作用以及含尿嘧啶DNA噬菌体PBS2感染后对其的抑制作用进行了研究。PBS2 DNA的水解产物，其尿嘧啶和胞嘧啶残基用氚标记，仅为尿嘧啶而非脱氧尿苷。在PBS2感染后7分钟内，在任何其他已知的PBS2诱导蛋白可检测到之前，降解活性被完全抑制。PBS2抑制剂（一种小的、热稳定蛋白）的产生一直持续到感染后10至20分钟。
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