萘啶酸对噬菌体SPO1感染的枯草芽孢杆菌中脱氧核糖核酸合成的影响。
Effect of nalidixic acid on deoxyribonucleic acid synthesis in bacteriophage SPO1-infected Bacillus subtilis.
作者信息
Gage L P, Fujita D J
出版信息
J Bacteriol. 1969 Apr;98(1):96-103. doi: 10.1128/jb.98.1.96-103.1969.
Abstract
The effect of nalidixic acid on deoxyribonucleic acid (DNA) synthesis in Bacillus subtilis cells infected with bacteriophage SPO1 was studied. Nalidixic acid had little inhibitory effect on SPO1 DNA synthesis at concentrations that drastically inhibited B. subtilis DNA synthesis. Inhibition of DNA synthesis, appropriate to the concentration used, was imposed within 1 min after addition of nalidixic acid, suggesting that it acts directly on DNA synthesis in both infected and uninfected cells. The SPO1 DNA synthesized in the presence of high concentrations of nalidixic acid had a density characteristic of normal SPO1 DNA and was packaged into viable progeny phage particles, but its rate of synthesis was reduced and bacterial lysis was delayed.
摘要
研究了萘啶酸对感染噬菌体SPO1的枯草芽孢杆菌细胞中脱氧核糖核酸（DNA）合成的影响。在能显著抑制枯草芽孢杆菌DNA合成的浓度下，萘啶酸对SPO1 DNA合成几乎没有抑制作用。在添加萘啶酸后1分钟内，就会根据所用浓度对DNA合成产生抑制作用，这表明它直接作用于感染和未感染细胞中的DNA合成。在高浓度萘啶酸存在下合成的SPO1 DNA具有正常SPO1 DNA的密度特征，并被包装成有活力的子代噬菌体颗粒，但其合成速率降低，细菌裂解延迟。
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