Daum F, Gould H B, Gold D, Dinari G, Friedman A H, Zucker P, Cohen M I
Am J Dis Child. 1979 Feb;133(2):170-1. doi: 10.1001/archpedi.1979.02130020062012.
Although acute anterior uveitis has been noted in children with inflammatory bowel disease, it has not been appreciated in the absence of ocular symptoms. To determine the presence of asymptomatic uveitis, slit-lamp examinations were performed in 19 children with granulomatous bowel disease and seven with ulcerative colitis. In the former group, six had uveitis, while no abnormalities were noted in those with ulcerative colitis. Abnormalities consisted of cells and flare in the anterior chamber. In the group with asymptomatic uveitis, all were male, three were black, and all had colonic involvement. No positive correlations were noted between the presence of uveitis and bowel symptoms, duration of illness, extraintestinal manifestations, or specific treatment regimens. None of the six children with uveitis had evidence of spondylitis, and five were HLA-B27-negative. Repeated eye examinations six to 12 months later disclosed no evidence of uveitis in four of five children and improvement in the remaining child. These data suggest that asymptomatic transient uveitis is common in children with granulomatous bowel disease, but progression to severe adult uveal disease remains unclear.
尽管急性前葡萄膜炎在炎症性肠病患儿中已有报道，但在无眼部症状时却未受到重视。为了确定无症状葡萄膜炎的存在情况，对19例肉芽肿性肠病患儿和7例溃疡性结肠炎患儿进行了裂隙灯检查。在前一组中，6例有葡萄膜炎，而溃疡性结肠炎患儿未发现异常。异常表现为前房内有细胞和闪光。在无症状葡萄膜炎组中，均为男性，3例为黑人，且均有结肠受累。葡萄膜炎的存在与肠道症状、病程、肠外表现或特定治疗方案之间未发现正相关。6例葡萄膜炎患儿均无脊柱炎证据，5例HLA - B27阴性。6至12个月后重复眼部检查发现，5例患儿中有4例无葡萄膜炎证据，其余1例有所改善。这些数据表明，无症状短暂性葡萄膜炎在肉芽肿性肠病患儿中很常见，但发展为严重的成人葡萄膜疾病情况仍不清楚。
