急性脑膜炎球菌血症的预后因素
Prognostic factors in acute meningococcaemia.
作者信息
Lewis L S
出版信息
Arch Dis Child. 1979 Jan;54(1):44-8. doi: 10.1136/adc.54.1.44.
Abstract
During a meningococcal (group A) epidemic, 47 Nigerian children with acute meningococcaemia without meningitis were studied. Their mortality rate was 43% compared with 8% during the whole epidemic. Those presenting with coma and shock had a mortality of 93%, but without shock or coma mortality was only 6%. Coma or shock occurring alone carried an intermediate prognosis. The outcome correlated with initial serum antigen titre, but not with the serum levels of endotoxin, cortisol, or fibrin degradation products. Chloramphenicol was as effective as penicillin. A predictor of expected mortality, based on serum antigen titre and the presence of coma or shock, may allow new forms of treatment to be assessed.
摘要
在一次A群脑膜炎球菌性流行期间，对47例患有急性脑膜炎球菌血症但无脑膜炎的尼日利亚儿童进行了研究。他们的死亡率为43%，而整个流行期间的死亡率为8%。出现昏迷和休克的患儿死亡率为93%，但无休克或昏迷的患儿死亡率仅为6%。单独出现昏迷或休克的患儿预后中等。结果与初始血清抗原滴度相关，但与内毒素、皮质醇或纤维蛋白降解产物的血清水平无关。氯霉素与青霉素疗效相当。基于血清抗原滴度以及昏迷或休克的存在情况预测预期死亡率，可能有助于评估新的治疗方式。
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