流产布鲁氏菌光滑型噬菌体抗性变异株的研究。I. 免疫学特性。
Studies on a smooth phage-resistant variant of Brucella abortus. I. Immunological properties.
作者信息
Corbel M J, Morris J A
出版信息
Br J Exp Pathol. 1974 Feb;55(1):78-87.
Abstract
The immunological properties of a phage-resistant variant of were examined. This variant, which was smooth and identical with the phage-susceptible parent strain in all cultural, biochemical and serological properties studied, was strongly antigenic in rabbits and guineapigs, inducing high titres of antibodies and delayed hypersensitivity to antigens. It was also fully virulent for mice and guinea-pigs. Contrary to other reports on the properties of phage-resistant Brucella strains, the properties of this strain showed no evidence of attenuation of virulence.
摘要
对一种噬菌体抗性变体的免疫学特性进行了检测。该变体表面光滑，在所有研究的培养、生化和血清学特性方面与噬菌体敏感亲代菌株相同，在兔和豚鼠中具有强抗原性，可诱导产生高滴度抗体以及对该抗原的迟发型超敏反应。它对小鼠和豚鼠也具有完全的毒性。与其他关于噬菌体抗性布鲁氏菌菌株特性的报道相反，该菌株的特性未显示出毒力减弱的迹象。
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