Sarsfield J K, Gowland G, Toy R, Norman A L
Arch Dis Child. 1974 Sep;49(9):716-21. doi: 10.1136/adc.49.9.716.
A trial of the effects of measures designed to reduce exposure to house-dust mites was performed on 14 children with mite-sensitive asthma. These measures reduced mite infestation of the beds and were associated with clinical improvement of asthmatic symptoms. Immunological studies revealed a tendency for levels of total serum IgE to fall during the course of the trial, but no such changes were apparent in the levels of anti-mite specific serum IgE. Possible reasons for this discrepancy are discussed. The conclusion of the study is that the use of a plastic mattress cover and the other inexpensive and harmless avoidance measures described should be advised for all asthmatic children with evidence of mite-sensitivity before resort to drug prophylaxis or hyposensitization procedures.
对14名对螨虫敏感的哮喘儿童进行了一项旨在减少接触屋尘螨措施效果的试验。这些措施减少了床上的螨虫滋生，并与哮喘症状的临床改善相关。免疫学研究显示，在试验过程中总血清IgE水平有下降趋势，但抗螨虫特异性血清IgE水平无明显变化。讨论了这种差异的可能原因。该研究的结论是，对于所有有螨虫敏感证据的哮喘儿童，在采取药物预防或减敏程序之前，应建议使用塑料床垫罩及所描述的其他廉价且无害的规避措施。
