McAllen M K, Assem E S, Maunsell K
Br Med J. 1970 May 30;2(5708):501-4. doi: 10.1136/bmj.2.5708.501.
Twenty-eight patients with asthma and house-dust allergy were investigated by five different challenge tests with mite extract (Dermatophagoides pteronyssinus). These tests were performed on the skin, bronchi, nasal mucosa, and leucocytes, and on normal human lung tissue passively sensitized by the patients' serum. The results were compared with each other and with the clinical state of the patients.Of 21 patients on whom all five tests were carried out, positive reactions to every test were found in 14 (67%). Asthmatic attacks were readily induced by inhalation of the mite extract and occurred in 18 (86%). Nasal reactions were provoked in 18 (86%) and were not followed by asthmatic symptoms. A leucocyte test was positive in 19 (90%) and the serum test was positive in all (100%). Delayed asthmatic responses to bronchial challenge were seen in six patients, but there was no evidence that these were mediated by precipitins. Quantitatively there was no fixed pattern between the degrees of sensitivity of the different tissues in the same patient. The amount of mite antigen capable of causing an asthmatic reaction was extremely small-less than 1 mug. of mite material in several patients.In view of the prevalence of D. pteronyssinus in this country and its high allergenic potency, it is considered that this mite is an important factor in allergic asthma.
对28例患有哮喘和屋尘过敏的患者，采用五种不同的螨提取物（粉尘螨）激发试验进行研究。这些试验在皮肤、支气管、鼻黏膜、白细胞以及由患者血清被动致敏的正常人肺组织上进行。将结果相互比较，并与患者的临床状况进行比较。在进行了所有五项试验的21例患者中，14例（67%）各项试验均呈阳性反应。吸入螨提取物很容易诱发哮喘发作，18例（86%）出现发作。18例（86%）出现鼻反应，但未继发哮喘症状。白细胞试验19例（90%）呈阳性，血清试验全部（100%）呈阳性。6例患者出现对支气管激发试验的迟发性哮喘反应，但没有证据表明这些反应是由沉淀素介导的。从数量上看，同一患者不同组织的敏感程度之间没有固定模式。能引起哮喘反应的螨抗原量极少——几名患者中不到1微克螨物质。鉴于该国粉尘螨的普遍存在及其高致敏性，认为这种螨是过敏性哮喘的一个重要因素。
