铜绿假单胞菌中一种产生阿米卡星（BB-K8）、丁胺卡那霉素、卡那霉素、妥布霉素和西索米星抗性的R质粒的特性
Properties of an R plasmid in Pseudomonas aeruginosa producing amikacin (BB-K8), butirosin, kanamycin, tobramycin, and sisomicin resistance.
作者信息
Jacoby G A
出版信息
Antimicrob Agents Chemother. 1974 Dec;6(6):807-10. doi: 10.1128/AAC.6.6.807.
Abstract
Pseudomonas aeruginosa strain GN315, producing kanamycin acetyltransferase, can transmit a plasmid determining resistance to kanamycin, amikacin (BB-K8), butirosin, tobramycin, and sisomicin, but not gentamicin, to other pseudomonas strains. This plasmid, pMG5, belongs to the same incompatibility group as plasmids determining gentamicin resistance in P. aeruginosa via gentamicin acetyltransferase I. Like other members of this group, it also confers resistance to Hg(2+), organomercurials, and certain deoxyribonucleic acid phages. When pMG5 is introduced into a cell carrying a related R factor, some transconjugants can subsequently cotransfer new combinations of resistance determinants as though recombinant plasmids had been formed.
摘要
产卡那霉素乙酰转移酶的铜绿假单胞菌菌株GN315能够将一个决定对卡那霉素、阿米卡星（BB-K8）、丁胺卡那霉素、妥布霉素和西索米星耐药性的质粒传递给其他假单胞菌菌株，但不能传递给庆大霉素。该质粒pMG5与通过庆大霉素乙酰转移酶I决定铜绿假单胞菌对庆大霉素耐药性的质粒属于同一不相容群。与该群的其他成员一样，它也赋予对Hg(2+)、有机汞化合物和某些脱氧核糖核酸噬菌体的耐药性。当将pMG5导入携带相关R因子的细胞时，一些转接合子随后能够共传递耐药决定子的新组合，就好像已经形成了重组质粒一样。
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Properties of an R plasmid in Pseudomonas aeruginosa producing amikacin (BB-K8), butirosin, kanamycin, tobramycin, and sisomicin resistance.铜绿假单胞菌中一种产生阿米卡星（BB-K8）、丁胺卡那霉素、卡那霉素、妥布霉素和西索米星抗性的R质粒的特性
Antimicrob Agents Chemother. 1974 Dec;6(6):807-10. doi: 10.1128/AAC.6.6.807.
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本文引用的文献
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Properties of R plasmids determining gentamicin resistance by acetylation in Pseudomonas aeruginosa.铜绿假单胞菌中通过乙酰化作用决定庆大霉素耐药性的R质粒特性
Antimicrob Agents Chemother. 1974 Sep;6(3):239-52. doi: 10.1128/AAC.6.3.239.
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Enzymatic inactivation of a new aminoglycoside antibiotic, sisomicin by resistant strains of Pseudomonas aeruginosa.铜绿假单胞菌耐药菌株对新氨基糖苷类抗生素西索米星的酶促失活作用。
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