青霉素：对巨大芽孢杆菌细胞中前芽孢隔膜发育的可逆抑制作用。
Penicillin: reversible inhibition of forespore septum development in Bacillus megaterium cells.
作者信息
Lawrence P J
出版信息
Antimicrob Agents Chemother. 1974 Dec;6(6):815-20. doi: 10.1128/AAC.6.6.815.
Abstract
Benzylpenicillin inhibits the development of the forespore septum in sporulating Bacillus megaterium cells. The inhibitory effect is a function of the duration of exposure to the antibiotic and is completely reversible by penicillinase. Under the incubation conditions employed, less than 20% of the covalently bound antibiotic is released from the cells. The penicillin which remains bound to the cells after treatment with penicillinase may be necessary but is not sufficient for the effect; unbound antibiotic in the sporulation medium is also required.
摘要
苄青霉素可抑制巨大芽孢杆菌孢子形成细胞中前芽孢隔膜的发育。抑制作用是接触抗生素持续时间的函数，并且可被青霉素酶完全逆转。在所采用的培养条件下，不到20%的共价结合抗生素从细胞中释放出来。用青霉素酶处理后仍与细胞结合的青霉素可能是产生该效应所必需的，但并不充分；芽孢形成培养基中的未结合抗生素也是必需的。
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Antimicrob Agents Chemother. 1974 Dec;6(6):815-20. doi: 10.1128/AAC.6.6.815.
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引用本文的文献
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本文引用的文献
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The site of action of penicillin. 1. Uptake of penicillin on bacteria.青霉素的作用位点。1. 青霉素在细菌上的摄取。
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Protein measurement with the Folin phenol reagent.使用福林酚试剂进行蛋白质测定。
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The binding of penicillin in relation to its cytotoxic action. IV. The amounts bound by bacteria at ineffective, growth-inhibitory, bactericidal, and maximally effective concentrations.青霉素结合与其细胞毒性作用的关系。IV. 细菌在无效、生长抑制、杀菌和最大有效浓度下结合的量。
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TRACE METAL REQUIREMENTS FOR SPORULATION OF BACILLUS MEGATERIUM.巨大芽孢杆菌芽孢形成所需的痕量金属
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Site of action of radiopenicillin.放射性青霉素的作用部位。
Bacteriol Rev. 1956 Mar;20(1):28-48. doi: 10.1128/br.20.1.28-48.1956.
6
The multiple mechanisms of penicillin resistance.青霉素耐药的多种机制。
J Bacteriol. 1954 Nov;68(5):610-6. doi: 10.1128/jb.68.5.610-616.1954.
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The binding of penicillin in relation to its cytotoxic action. I. Correlation between the penicillin sensitivity and combining activity of intact bacteria and cell-free extracts.青霉素结合与其细胞毒性作用的关系。I. 完整细菌和无细胞提取物的青霉素敏感性与结合活性之间的相关性。
J Exp Med. 1954 Mar;99(3):207-26. doi: 10.1084/jem.99.3.207.
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Correlation between growth inhibition and the binding of various penicillins and cephalosporins to Staphylococcus aureus.生长抑制与各种青霉素和头孢菌素与金黄色葡萄球菌结合之间的相关性。
J Bacteriol. 1969 Aug;99(2):459-62. doi: 10.1128/jb.99.2.459-462.1969.
9
Sporulation of a cortexless mutant of a variant of Bacillus cereus.蜡样芽孢杆菌一个变种的无芽孢外壁突变体的芽孢形成
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10
Antibiotic inhibition of the septation stage in sporulation of Bacillus megaterium.抗生素对巨大芽孢杆菌芽孢形成中隔膜形成阶段的抑制作用。
J Bacteriol. 1969 Mar;97(3):1513-5. doi: 10.1128/jb.97.3.1513-1515.1969.
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