Eaglstein W H, Sakai M, Mizuno N
J Invest Dermatol. 1979 Feb;72(2):59-63. doi: 10.1111/1523-1747.ep12530248.
To evaluate the role of leukocytes in inflammation induced by ultraviolet radiation, the response of guinea pigs make leukopenic with cyclophosphamide was compared with the response of nonleukopenic animals. The response of leukopenic animals to UVB (295 nm) was significantly altered. Leukopenic animals and saline-treated (i.e., nonleukopenic) animals responded similarly to (1) UVC (250 nm), (2) UVA (340 nm) given after 8-methoxypsoralen pretreatment (PUVA), (3) intradermal histamine and (4) a topically applied prostaglandin analogue. These results suggest that leukocytes are important in UVB-induced inflammation but not in the inflammation induced by UVC or PUVA.
为评估白细胞在紫外线辐射诱导的炎症中的作用，将用环磷酰胺造成白细胞减少的豚鼠的反应与未出现白细胞减少的动物的反应进行了比较。白细胞减少的动物对UVB（295纳米）的反应发生了显著改变。白细胞减少的动物和用盐水处理的（即未出现白细胞减少的）动物对以下几种情况的反应相似：（1）UVC（250纳米）；（2）8-甲氧基补骨脂素预处理后给予的UVA（340纳米）（光化学疗法）；（3）皮内注射组胺；（4）局部应用前列腺素类似物。这些结果表明，白细胞在UVB诱导的炎症中起重要作用，但在UVC或光化学疗法诱导的炎症中则不然。
