Loughlin G M, Taussig L M
J Pediatr. 1979 Mar;94(3):365-9. doi: 10.1016/s0022-3476(79)80572-7.
Baseline, postexercise, and postisoproterenol lung function was studied in 27 children, 8 to 18 years of age, with a past history of laryngotracheobronchitis (croup) and in ten children without such a history. The LTB subjects were divided into two groups, based on the presence or absence of allergies. Baseline flow tests were similar in all groups but small airway function was mildly abnormal in several members of each group. There was no consistent response to isoproterenol inhalation among those who had had croup and normal subjects. Following exercise, however, a significant (P less than 0.05) number of subjects (14 of 27) in both LTB groups demonstrated bronchoconstriction with a greater than 10% drop in peak expiratory flows. From these studies, it appears that children with a past history of croup have a higher prevalence of increased bronchial reactivity, which occurs irrespective of allergy and baseline lung function abnormalities.
对27名8至18岁有喉气管支气管炎（哮吼）病史的儿童以及10名无此病史的儿童进行了运动前、运动后和异丙肾上腺素激发后的肺功能研究。根据是否存在过敏，将患哮吼的受试者分为两组。所有组的基础流量测试结果相似，但每组均有几名成员的小气道功能轻度异常。哮吼患者和正常受试者对异丙肾上腺素吸入均无一致反应。然而，运动后，两个患哮吼组中均有相当数量（27名中的14名）的受试者出现支气管收缩，呼气峰值流量下降超过10%。从这些研究来看，有哮吼病史的儿童支气管反应性增加的患病率较高，且这种情况与过敏和基础肺功能异常无关。
