Martin L, Finn C A
J Reprod Fertil. 1979 Jan;55(1):125-33. doi: 10.1530/jrf.0.0550125.
Chronically implanted IUDs consisting of silk suture threads induced decidualization in regions of the uterus remote from the suture site in ovariectomized mice treated with a regimen of progesterone and oestrogen which sensitizes the uterus to a decidual stimulus. In these conditions the IUDs did not inhibit decidualization induced by instilled oil, although they did so in pregnant animals of the same strain. Varying the dose of progesterone and oestrogen did not produce conditions in which IUD's inhibited oil-induced decidualization in ovariectomized mice and progesterone treatment did not prevent IUDs inhibiting decidualization in pregnant animals. However, when ovariectomized mice, sensitized as before, were primed repeatedly with oestrogen to simulate continuing oestrous cycles after IUD insertion, the IUD's inhibited oil-induced decidualization. This involved the premature loss of instilled oil from the uterine lumen and was associated with heavy infiltration of leucocytes into the luminal epithelium. Numbers of leucocytes free in the uterine lumen did not appear to be critical. It appears that contact between the oil and the luminal epithelial surface must be sustained for some length of time to induce a decidual reaction; brief contact is not sufficient to trigger the response.
由丝线制成的慢性植入式宫内节育器（IUD），在接受了能使子宫对蜕膜化刺激敏感的孕酮和雌激素治疗方案的去卵巢小鼠中，于子宫远离缝线部位的区域诱发了蜕膜化。在这些条件下，IUD并没有抑制注入油所诱导的蜕膜化，尽管它们在同一品系的怀孕动物中能起到抑制作用。改变孕酮和雌激素的剂量，并没有产生使IUD在去卵巢小鼠中抑制油诱导的蜕膜化的条件，而且孕酮治疗也不能防止IUD在怀孕动物中抑制蜕膜化。然而，当如前所述致敏的去卵巢小鼠反复用雌激素预处理，以模拟IUD插入后持续的发情周期时，IUD抑制了油诱导的蜕膜化。这涉及子宫腔内注入油的过早流失，并与白细胞大量浸润到腔上皮有关。子宫腔内游离的白细胞数量似乎并不关键。看来油与腔上皮表面之间的接触必须持续一段时间才能诱导蜕膜反应；短暂接触不足以触发该反应。
