Martin L, Finn C A
J Endocrinol. 1978 Sep;78(3):417-25. doi: 10.1677/joe.0.0780417.
Silk threads placed in the uteri of ovariectomized mice increased cell proliferation in all tissues including regions of the uterus remote from the site of insertion. Many of the effects resembled those produced by oestrogens. An intra-uterine device (IUD) increased luminal and glandular mitosis and produced various degrees of luminal epithelial hyperplasia in untreated animals. In progesterone-treated mice bearing IUD's, luminal and stromal mitosis was increased. Epithelial morphology was not affected or luminal mitosis inhibited in oestrogen-treated animals with IUD's, but stromal and glandular mitosis was increased. After combined treatment with progesterone and oestrogen, stromal mitosis was suppressed at the contact site but was increased elsewhere. Both oestrogen and progesterone suppressed the luminal leucocytosis induced by the IUD. Despite this, the IUD prevented complete progestational differentiation of the luminal epithelium and closure of the lumen. The degree to which IUD-induced abnormalities were observed depended on the hormonal status of the animal at the time of sampling.
将丝线置于去卵巢小鼠子宫内，可增加包括远离丝线插入部位的子宫区域在内的所有组织中的细胞增殖。许多效应类似于雌激素产生的效应。宫内节育器（IUD）可增加未处理动物的管腔和腺体有丝分裂，并产生不同程度的管腔上皮增生。在接受孕酮治疗并带有宫内节育器的小鼠中，管腔和基质有丝分裂增加。在接受雌激素治疗并带有宫内节育器的动物中，上皮形态未受影响或管腔有丝分裂受到抑制，但基质和腺体有丝分裂增加。在孕酮和雌激素联合治疗后，接触部位的基质有丝分裂受到抑制，但其他部位增加。雌激素和孕酮均可抑制宫内节育器诱导的管腔白细胞增多。尽管如此，宫内节育器仍可阻止管腔上皮的完全孕激素分化和管腔闭合。观察到的宫内节育器诱导异常的程度取决于取样时动物的激素状态。
