细胞外钠离子对红细胞钠泵的影响。
The influence of external sodium ions on the sodium pump in erythrocytes.
作者信息
Priestland R N, Whittam R
出版信息
Biochem J. 1968 Sep;109(3):369-74. doi: 10.1042/bj1090369.
Abstract
- A study has been made of the interaction between Na(+) and K(+) on the adenosine triphosphatase activity of erythrocyte ;ghosts', and on the K(+) influx and Na(+) efflux of intact erythrocytes. The adenosine triphosphatase activity and the ion movements were greater at a low external K(+) concentration in the absence of Na(+) than they were in the presence of 150mm-Na(+). The inhibition by external Na(+) of K(+) influx had an inhibitory constant of 5-10mm. 2. Activation by K(+) of kidney microsomal adenosine triphosphatase was retarded by Na(+), and activation by Na(+) was retarded by K(+). Fragmented erythrocyte membranes behaved similarly. 3. These observations suggest that there is competition between Na(+) and K(+) at the K(+)-sensitive site of the membrane.
摘要
- 已经对钠（Na⁺）和钾（K⁺）之间的相互作用进行了研究，该相互作用涉及红细胞“血影”的三磷酸腺苷酶活性，以及完整红细胞的钾离子内流和钠离子外流。在不存在钠离子的情况下，低细胞外钾离子浓度时的三磷酸腺苷酶活性和离子运动比在存在150mmol/L钠离子时更高。细胞外钠离子对钾离子内流的抑制作用，其抑制常数为5 - 10mmol/L。2. 钾离子对肾微粒体三磷酸腺苷酶的激活作用受到钠离子的抑制，而钠离子的激活作用受到钾离子的抑制。破碎的红细胞膜表现出类似情况。3. 这些观察结果表明，在膜的钾离子敏感位点上，钠离子和钾离子之间存在竞争。
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本文引用的文献
1
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Biochem J. 1938 Feb;32(2):295-8. doi: 10.1042/bj0320295.
2
3
THE ROLE OF NA+ AND K+ IN THE OUABAIN-INHIBITION OF THE NA+ + K+-ACTIVATED MEMBRANE ADENOSINE TRIPHOSPHATASE.钠离子和钾离子在哇巴因对钠钾激活的膜三磷酸腺苷酶抑制作用中的角色。
Biochim Biophys Acta. 1965 Jan 25;94:89-96. doi: 10.1016/0926-6585(65)90011-7.
4
The asymmetrical stimulation of a membrane adenosine triphosphatase in relation to active cation transport.与活性阳离子转运相关的膜三磷酸腺苷酶的不对称刺激。
Biochem J. 1962 Jul;84(1):110-8. doi: 10.1042/bj0840110.
5
Active transport, genetics, and cellular evolution.主动运输、遗传学与细胞进化。
Fed Proc. 1963 Jan-Feb;22:19-26.
6
The influence of some cations on an adenosine triphosphatase from peripheral nerves.某些阳离子对来自外周神经的三磷酸腺苷酶的影响。
Biochim Biophys Acta. 1957 Feb;23(2):394-401. doi: 10.1016/0006-3002(57)90343-8.
7
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J Physiol. 1956 Nov 28;134(2):278-310. doi: 10.1113/jphysiol.1956.sp005643.
8
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9
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