Geddes A M, Fothergill R, Goodall J A, Dorken P R
Br Med J. 1971 Aug;3(5772):451-4. doi: 10.1136/bmj.3.5772.451.
Fifty patients suffering from infections caused by various salmonella species were treated with trimethoprim-sulphamethoxazole compound. Twenty-three had enteric fever and two were biliary carriers of Salmonella typhi. The other 25 suffered from infections caused by salmonella species other than S. typhi or S. paratyphi B. Twenty-one of the patients with enteric fever responded clinically to the drug, one failed treatment, and one died. Two patients suffering from typhoid fever relapsed and three temporarily excreted S. typhi in stools following treatment. One of the typhoid carriers was successfully treated. All patients with infections caused by salmonella species other than S. typhi or S. paratyphi B responded to treatment but 17 continued to excrete the organism in their stools after the course of trimethoprim-sulphamethoxazole compound. Four patients developed rashes during therapy and two became anaemic.
五十名患有各种沙门氏菌感染的患者接受了甲氧苄啶 - 磺胺甲恶唑复方治疗。其中23人患有伤寒热，2人是伤寒杆菌的胆道携带者。另外25人患有除伤寒沙门氏菌或副伤寒乙沙门氏菌以外的其他沙门氏菌引起的感染。21名伤寒热患者对该药物有临床反应，1人治疗失败，1人死亡。两名伤寒热患者复发，三名患者在治疗后粪便中暂时排出伤寒杆菌。一名伤寒携带者得到成功治疗。所有患有除伤寒沙门氏菌或副伤寒乙沙门氏菌以外的其他沙门氏菌感染的患者对治疗均有反应，但在甲氧苄啶 - 磺胺甲恶唑复方疗程结束后，17人仍在粪便中排出该病菌。四名患者在治疗期间出现皮疹，两名患者出现贫血。
