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复方新诺明在营养性造血素缺乏中的毒性。

Toxicity of co-trimoxazole in nutritional haematinic deficiency.

作者信息

Hill A V, Kerr D N

出版信息

Postgrad Med J. 1973 Aug;49(574):596-8. doi: 10.1136/pgmj.49.574.596.

Abstract

A woman of 47 habituated to analgesics and living on an inadequate diet was deficient in iron, folate and vitamin B. Treatment of pyelonephritis with co-trimoxazole precipitated pancytopenia with a megaloblastic bone marrow. She recovered following withdrawal of the drug and administration of iron, folate and vitamin B.

摘要

一名47岁的女性,长期服用镇痛药且饮食不均衡,体内缺乏铁、叶酸和维生素B。用复方新诺明治疗肾盂肾炎后引发了全血细胞减少症,并伴有巨幼细胞性骨髓。在停用该药物并补充铁、叶酸和维生素B后,她康复了。

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本文引用的文献

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Renal papillary necrosis with a normal pyelogram.
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Trimethoprim: laboratory and clinical studies.甲氧苄啶:实验室研究与临床研究
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Thrombocytopenia following administration of "septrin".
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Effects of trimethoprim on folate metabolism in man.
Clin Pharmacol Ther. 1968 Sep-Oct;9(5):550-60. doi: 10.1002/cpt196895550.
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Drug neutropenia.药物性中性粒细胞减少症
Br Med J. 1970 May 9;2(5705):364. doi: 10.1136/bmj.2.5705.364-c.
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Analgesic nephropathy: clinical syndrome and prognosis.镇痛剂肾病:临床综合征与预后
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