阿莫西林的药代动力学：肾功能受损患者的剂量列线图。
Pharmacokinetics of amoxicillin: Dosage nomogram for patients with impaired renal function.
作者信息
Humbert G, Spyker D A, Fillastre J P, Leroy A
出版信息
Antimicrob Agents Chemother. 1979 Jan;15(1):28-33. doi: 10.1128/AAC.15.1.28.
Abstract
Amoxicillin pharmacokinetics after intravenous administration were studied in patients with normal renal function, with impaired renal function, and during hemodialysis. The average urinary recovery was 68% in patients with normal renal function. Serum half-life was highly correlated (r = 0.967) with creatinine clearance corrected for body weight. Expected half-life was 71 min for a corrected creatinine clearance of 100 ml/min per 70 kg and 16 h in the anephric patient. Average amoxicillin half-life on hemodialysis was 3.6 h. We present a dosage nomogram for making appropriate adjustments to loading dose based on patient weight and maintenance dose based on corrected creatinine clearance.
摘要
在肾功能正常、肾功能受损及血液透析期间的患者中研究了静脉注射阿莫西林后的药代动力学。肾功能正常的患者尿中阿莫西林平均回收率为68%。血清半衰期与校正体重后的肌酐清除率高度相关（r = 0.967）。校正肌酐清除率为每70 kg体重每分钟100 ml时，预期半衰期为71分钟，无肾患者的半衰期为16小时。血液透析时阿莫西林的平均半衰期为3.6小时。我们提供了一张剂量列线图，可根据患者体重对负荷剂量进行适当调整，并根据校正后的肌酐清除率对维持剂量进行调整。
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