Grimwood R, Swinehart J M, Aeling J L
Arch Dermatol. 1979 Feb;115(2):205-7.
Angiolymphoid hyperplasia with eosinophilia (AHE) is a distinct clinical and pathologic entity that demonstrates proliferation of endothelial cells associated with varying degrees of lymphocytic, histiocytic, and eosinophilic infiltration. Lymphoid hyperplasia with germinal centers often is present in older lesions and the patients may have an associated blood eosinophilia. Multiple deep nodules developed in a young man on the palmar aspect of the left hand, and subsequently the forehead, histologically diagnostic of AHE. Direct immunofluorescence of the tumor removed from the forehead demonstrated granular deposits of IgA, IgM, and C3 associated with small vessels. Cryoglobulins (IgA, IgM, and IgG) were found in the patient's serum. This new information lends support to the hypothesis that AHE is an inflammatory reactive lesion, possibly secondary to an immunologic injury, rather than a true vascular neoplasm with an associated inflammatory reaction.
嗜酸性粒细胞增多性血管淋巴样增生（AHE）是一种独特的临床和病理实体，表现为内皮细胞增殖，并伴有不同程度的淋巴细胞、组织细胞和嗜酸性粒细胞浸润。有生发中心的淋巴样增生常见于较老的病变中，患者可能伴有血液嗜酸性粒细胞增多。一名年轻男性左手掌面出现多个深部结节，随后前额也出现结节，组织学诊断为AHE。从额头上切除的肿瘤进行直接免疫荧光检查显示，IgA、IgM和C3的颗粒状沉积物与小血管有关。患者血清中发现了冷球蛋白（IgA、IgM和IgG）。这一新信息支持了以下假说：AHE是一种炎症反应性病变，可能继发于免疫损伤，而不是伴有炎症反应的真正血管肿瘤。
