Goodale R L, Condie R M, Dressel T D, Taylor T N, Gajl-Peczalska K
Ann Surg. 1979 Mar;189(3):340-4. doi: 10.1097/00000658-197903000-00015.
Pure pancreatic fluid was aspirated at the time of endoscopic retrograde cholangiopancreatography (ERCP), after Secretin stimulation, and was analyzed for protein in eight patients with proven adenocarcinoma of the pancreas and in 16 subjects of the same sex ratio and approximately matching ages, who had normal pancreatograms and pancreatic cytology, who served as controls. The albumin concentration, IgA, IgG, were all significantly greater in the pancreatic fluid of the cancer group, and the IgM and transferrin increase was of borderline significance. Many zymogen bands present in controls were either faintly present or absent in the cancer group at matching zymogen concentration. Cytology was positive or suspicious in eight of 11 cancer patients. The secretory protein abnormalities and cytology results in the cancer group did not depend on a particular tumor site or size, the smallest being 3 cm lesions. Hence, secretory abnormalities and gross tumor size and location are independent entities to a certain extent. It is possible that secretion changes may precede the development of gross tumor. Further study will be necessary before the actual significance of these findings for early diagnosis is known.
在内镜逆行胰胆管造影术（ERCP）时，经促胰液素刺激后，采集了8例经证实患有胰腺癌患者以及16例性别比例相同、年龄大致匹配且胰管造影和胰腺细胞学检查均正常的对照者的纯胰液，对其蛋白质进行分析。癌症组胰液中的白蛋白浓度、IgA、IgG均显著更高，IgM和转铁蛋白的增加具有临界显著性。在胰酶原浓度匹配的情况下，对照组中存在的许多胰酶原条带在癌症组中要么微弱存在要么缺失。11例癌症患者中有8例细胞学检查呈阳性或可疑。癌症组中的分泌蛋白异常和细胞学检查结果并不取决于特定的肿瘤部位或大小，最小的肿瘤为3厘米的病灶。因此，分泌异常与肿瘤的总体大小和位置在一定程度上是相互独立的。分泌变化有可能先于肿瘤的发生发展。在了解这些发现对早期诊断的实际意义之前，还需要进一步研究。
