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胰腺癌和慢性胰腺炎患者的人胰腺分泌蛋白谱

Human pancreatic secretory protein profiles in pancreas cancer and chronic pancreatitis.

作者信息

White T T, Allan B J, Schilling J J, Miyashita H

出版信息

Dig Dis Sci. 1985 Mar;30(3):200-3. doi: 10.1007/BF01347883.

DOI:10.1007/BF01347883
PMID:3971832
Abstract

Pancreatic secretory protein profiles differed significantly between patients with chronic pancreatitis (CP) and pancreatic carcinoma (CA). Specific regions of the patterns were altered when CP versus CA and when CP versus normals were compared. Bands isoelectric in the region of pH 9-11 were elevated in CP. The possible identification of this band as lactoferrin is discussed.

摘要

慢性胰腺炎（CP）患者和胰腺癌（CA）患者的胰腺分泌蛋白谱存在显著差异。当比较CP与CA以及CP与正常组时，图谱的特定区域发生了改变。在CP中，pH 9 - 11区域等电的条带升高。文中讨论了将该条带鉴定为乳铁蛋白的可能性。

相似文献

1
Human pancreatic secretory protein profiles in pancreas cancer and chronic pancreatitis.胰腺癌和慢性胰腺炎患者的人胰腺分泌蛋白谱
Dig Dis Sci. 1985 Mar;30(3):200-3. doi: 10.1007/BF01347883.
2
Human pancreatic secretory protein profiles in the search for tumor markers.寻找肿瘤标志物时的人胰腺分泌蛋白谱
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Scand J Gastroenterol. 1984 Mar;19(2):139-44.
4
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引用本文的文献

1
Analysis of pure pancreatic juice proteins by two-dimensional gel electrophoresis in cases of pancreatic cancer.
Gastroenterol Jpn. 1986 Dec;21(6):623-9. doi: 10.1007/BF02774491.

本文引用的文献

1
[Comparison of the proteins in pancreatic juice in normal and diseased humans. Determination of serum proteins and demonstration of a particular protein in chronic calcifying pancreatitis].[正常人与患病者胰液中蛋白质的比较。血清蛋白的测定及慢性钙化性胰腺炎中一种特定蛋白质的证实]
Biochim Biophys Acta. 1971 Dec 28;251(3):456-66.
2
[Lactoferrin in chronic calcifying pancreatitis. Hypothesis for the biological role of the protein].[慢性钙化性胰腺炎中的乳铁蛋白。该蛋白质生物学作用的假说]
Gastroenterol Clin Biol. 1980 Oct;4(10):631-5.
3
Techniques for reproducible transient-state isoelectric focusing of human pancreatic secretory proteins with computer-assisted pattern matching, averaging, and analysis.
采用计算机辅助模式匹配、平均化和分析技术对人胰腺分泌蛋白进行可重复的瞬态等电聚焦。
Anal Biochem. 1981 May 1;113(1):1-12. doi: 10.1016/0003-2697(81)90037-3.
4
Clinical and secretory differences in pancreatic cancer and chronic pancreatitis.胰腺癌与慢性胰腺炎的临床及分泌差异
Ann Surg. 1981 Aug;194(2):193-8. doi: 10.1097/00000658-198108000-00014.
5
Protein secretions in hamsters with pancreatic carcinoma.患有胰腺癌的仓鼠的蛋白质分泌情况。
Dig Dis Sci. 1982 May;27(5):437-43. doi: 10.1007/BF01295653.
6
Human pancreatic secretory protein profiles in the search for tumor markers.寻找肿瘤标志物时的人胰腺分泌蛋白谱
Dig Dis Sci. 1983 Sep;28(9):792-800. doi: 10.1007/BF01296901.
7
Abnormalities in pancreatic secretory profiles of patients with cancer of the pancreas.胰腺癌患者胰腺分泌谱的异常。
Dig Dis Sci. 1983 Feb;28(2):103-10. doi: 10.1007/BF01315138.
8
TIBIAS--a microcomputer-based analysis system for isoelectric focusing and electrophoretic patterns.TIBIAS——一种基于微型计算机的等电聚焦和电泳图谱分析系统。
Int J Biomed Comput. 1983 Jul;14(4):321-32. doi: 10.1016/0020-7101(83)90005-3.
9
Pancreatic secretory abnormalities precede appearance of tumors of the pancreas in hamsters treated with bis-(2-oxopropyl)-N-nitrosamine.
Dig Dis Sci. 1983 Jun;28(6):526-38. doi: 10.1007/BF01308155.
10
Biochemical analysis of secretory proteins synthesized by normal rat pancreas and by pancreatic acinar tumor cells.正常大鼠胰腺和胰腺腺泡肿瘤细胞合成的分泌蛋白的生化分析。
J Cell Biol. 1982 Dec;95(3):734-41. doi: 10.1083/jcb.95.3.734.