T4噬菌体混合感染中的选择性等位基因丢失。
Selective allele loss in mixed infections with T4 bacteriophage.
作者信息
Benz W C, Berger H
出版信息
Genetics. 1973 Jan;73(1):1-11. doi: 10.1093/genetics/73.1.1.
Abstract
Evidence is presented that when E. coli B is mixedly infected with T4D wild type and rII deletion mutants, the excess DNA of the wild type allele is lost. No loss is seen in mixed infections with rII point mutants and wild type. In similar experiments with lysozyme addition mutants, the mutant allele is lost. We believe these results demonstrate a repair system which removes "loops" in heteroduplex DNA molecules. A number of phage and host functions have been tested for involvement in the repair of the excess DNA, and T4 genes x and v have been implicated in this process.
摘要
有证据表明，当大肠杆菌B被T4D野生型和rII缺失突变体混合感染时，野生型等位基因的多余DNA会丢失。在rII点突变体与野生型的混合感染中未观察到DNA丢失。在添加溶菌酶突变体的类似实验中，突变等位基因会丢失。我们认为这些结果证明了一种修复系统，该系统可去除异源双链DNA分子中的“环”。已经测试了许多噬菌体和宿主功能是否参与多余DNA的修复，并且T4基因x和v与该过程有关。
相似文献
1
Selective allele loss in mixed infections with T4 bacteriophage.T4噬菌体混合感染中的选择性等位基因丢失。
Genetics. 1973 Jan;73(1):1-11. doi: 10.1093/genetics/73.1.1.
2
Suppression of T4D ligase mutations by rIIa and rIIb mutations.rIIa和rIIb突变对T4D连接酶突变的抑制作用。
Proc Natl Acad Sci U S A. 1969 Nov;64(3):897-904. doi: 10.1073/pnas.64.3.897.
3
Evidence that mismatched bases in heteroduplex T4 bacteriophage are recognized in vivo.体内可识别异源双链T4噬菌体中错配碱基的证据。
J Virol. 1976 Nov;20(2):441-5. doi: 10.1128/JVI.20.2.441-445.1976.
4
Bacteriophage-induced functions in Escherichia coli K (lambda) infected with rII mutants of bacteriophage T4.噬菌体T4的rII突变体感染大肠杆菌K（λ）后噬菌体诱导的功能。
J Bacteriol. 1966 Jan;91(1):76-80. doi: 10.1128/jb.91.1.76-80.1966.
5
Recombination in bacteriophage T4: a mechanism.噬菌体T4中的重组：一种机制。
Science. 1965 Nov 5;150(3697):760-3. doi: 10.1126/science.150.3697.760.
6
das Mutation in bacteriophage T4D does not suppress an amber mutation in T4 gene 59.噬菌体T4D中的突变不能抑制T4基因59中的琥珀突变。
J Virol. 1975 Nov;16(5):1348-50. doi: 10.1128/JVI.16.5.1348-1350.1975.
7
Replication and recombination of gene 59 mutant of bacteriophage T4D.噬菌体T4D基因59突变体的复制与重组
J Virol. 1975 Jan;17(1):175-82. doi: 10.1128/JVI.17.1.175-182.1976.
8
Defective concatemer formation in cells infected with deoxyribonucleic acid-delay mutants of bacteriophage T4.感染噬菌体T4的脱氧核糖核酸延迟突变体的细胞中连接体形成缺陷。
J Virol. 1972 Oct;10(4):858-62. doi: 10.1128/JVI.10.4.858-862.1972.
9
Reversion of frameshift mutations stimulated by lesions in early function genes of bacteriophage T4.噬菌体T4早期功能基因损伤刺激的移码突变回复
J Virol. 1971 Apr;7(4):460-6. doi: 10.1128/JVI.7.4.460-466.1971.
10
Mutants of bacteriophage T4 deficient in the ability to induce nuclear disruption: shutoff of host DNA and protein synthesis gene dosage experiments, identification of a restrictive host, and possible biological significance.噬菌体T4中缺乏诱导核破坏能力的突变体：宿主DNA和蛋白质合成的关闭、基因剂量实验、限制性宿主的鉴定以及可能的生物学意义。
J Virol. 1976 Apr;18(1):268-88. doi: 10.1128/JVI.18.1.268-288.1976.
引用本文的文献
1
Distribution and Frequency of Tandem Duplications of the rII Region of Bacteriophage T4d.噬菌体 T4d 的 rII 区串联重复的分布和频率。
Genetics. 1977 Dec;87(4):593-619. doi: 10.1093/genetics/87.4.593.
2
Rates of spontaneous mutation in bacteriophage T4 are independent of host fidelity determinants.噬菌体T4中的自发突变率与宿主保真度决定因素无关。
Genetics. 1994 Nov;138(3):553-64. doi: 10.1093/genetics/138.3.553.
3
Region-specific recombination in phage T4. II. Structure of the recombinants.噬菌体T4中的区域特异性重组。II. 重组体的结构。
Genetics. 1980 Mar;94(3):531-47. doi: 10.1093/genetics/94.3.531.
4
UV irradiation impairs in vivo encapsidation of bacteriophage T4 DNA.紫外线照射会损害噬菌体T4 DNA在体内的包装。
J Virol. 1984 May;50(2):293-300. doi: 10.1128/JVI.50.2.293-300.1984.
5
Effects of nonhomology on bacteriophage lambda recombination.非同源性对噬菌体λ重组的影响。
Genetics. 1983 Jan;103(1):5-22. doi: 10.1093/genetics/103.1.5.
6
Identification, physical map location and sequence of the denV gene from bacteriophage T4.噬菌体T4中denV基因的鉴定、物理图谱定位及序列分析
Nucleic Acids Res. 1984 Nov 12;12(21):8085-96. doi: 10.1093/nar/12.21.8085.
7
Symposium No. 5: Genetic exchange. Introduction by the Chairman. Advances in recombination research.第5场研讨会：基因交换。主席致辞。重组研究进展。
Genetics. 1974 Sep;78(1):237-45. doi: 10.1093/genetics/78.1.237.
8
Mitochondrial genetics in Bakers' yeast: a molecular mechanism for recombinational polarity and suppressiveness.面包酵母中的线粒体遗传学：重组极性和抑制性的分子机制。
Proc Natl Acad Sci U S A. 1974 Nov;71(11):4612-6. doi: 10.1073/pnas.71.11.4612.
9
Initiation of heteroduplex-loop repair by T4-encoded endonuclease VII in vitro.T4编码的核酸内切酶VII在体外启动异源双链环修复。
EMBO J. 1988 May;7(5):1527-35. doi: 10.1002/j.1460-2075.1988.tb02972.x.
10
T4 phage gene uvsX product catalyzes homologous DNA pairing.T4噬菌体基因uvsX产物催化同源DNA配对。
EMBO J. 1985 Dec 1;4(12):3321-7. doi: 10.1002/j.1460-2075.1985.tb04083.x.
本文引用的文献
1
High Negative Interference over Short Segments of the Genetic Structure of Bacteriophage T4.噬菌体T4遗传结构短片段上的高负干扰
Genetics. 1958 May;43(3):332-53. doi: 10.1093/genetics/43.3.332.
2
The nature of the "deletion" mutants in the rII region of phage T4.噬菌体T4 rII区域中“缺失”突变体的性质。
J Mol Biol. 1961 Oct;3:684-92. doi: 10.1016/s0022-2836(61)80031-4.
3
Mutants of phage T4 with increased sensitivity to ultraviolet.对紫外线敏感性增强的噬菌体T4突变体。
Virology. 1963 Jan;19:66-71. doi: 10.1016/0042-6822(63)90025-4.
4
Mapping of deletions and substitutions in heteroduplex DNA molecules of bacteriophage lambda by electron microscopy.通过电子显微镜对噬菌体λ异源双链DNA分子中的缺失和替换进行定位
Science. 1969 Mar 21;163(3873):1343-8. doi: 10.1126/science.163.3873.1343.
5
Hycanthone: a frameshift mutagen.海蒽酮：一种移码诱变剂。
Science. 1971 Jun 4;172(3987):1058-60. doi: 10.1126/science.172.3987.1058.
6
Frameshift mutation in the lysozyme gene of bacteriophage T4: demonstration of the insertion of five bases, and a summary of in vivo codons and lysozyme activities.噬菌体T4溶菌酶基因中的移码突变：五个碱基插入的证明以及体内密码子和溶菌酶活性的总结
J Mol Biol. 1970 Dec 14;54(2):219-46. doi: 10.1016/0022-2836(70)90428-6.
7
Effects of deletion mutations on high negative interference in T4D bacteriophage.缺失突变对T4D噬菌体高负干扰的影响。
Genetics. 1969 Sep;63(1):1-5. doi: 10.1093/genetics/63.1.1.
8
Heteroduplex heterozygotes in bacteriophage T4 involving mutations of various dimensions.噬菌体T4中涉及各种大小突变的异源双链杂合子。
Proc Natl Acad Sci U S A. 1966 Mar;55(3):506-12. doi: 10.1073/pnas.55.3.506.
9
Genetic control of mutation rates in bacteriophageT4.噬菌体T4中突变率的遗传控制。
Nature. 1969 Mar 22;221(5186):1128-32.
10
The identification of complex genotypes in bacteriophage T4. I. Methods.噬菌体T4中复杂基因型的鉴定。I. 方法。
Genetics. 1970 Nov;66(3):417-28. doi: 10.1093/genetics/66.3.417.
Zotero 插件