体内可识别异源双链T4噬菌体中错配碱基的证据。
Evidence that mismatched bases in heteroduplex T4 bacteriophage are recognized in vivo.
作者信息
Berger H, Pardoll D
出版信息
J Virol. 1976 Nov;20(2):441-5. doi: 10.1128/JVI.20.2.441-445.1976.
Abstract
T4 heteroduplex heterozygotes are lost selectively after prolonged incubation of phage-infected Escherichia coli cells under nonreplicating conditions. The loss of heterozygosity occurs for four out of six rII sites tested and is not dependent upon T4 v gene function. The results are interpreted to indicate the existence of a base-specific system for the recognition of mismatched bases in intracellular DNA.
摘要
在非复制条件下对噬菌体感染的大肠杆菌细胞进行长时间培养后，T4异源双链杂合子会被选择性地丢失。在所测试的六个rII位点中的四个位点出现了杂合性的丧失，并且这并不依赖于T4 v基因的功能。这些结果被解释为表明细胞内DNA中存在一种识别错配碱基的碱基特异性系统。
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