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体内可识别异源双链T4噬菌体中错配碱基的证据。

Evidence that mismatched bases in heteroduplex T4 bacteriophage are recognized in vivo.

作者信息

Berger H, Pardoll D

出版信息

J Virol. 1976 Nov;20(2):441-5. doi: 10.1128/JVI.20.2.441-445.1976.

DOI:10.1128/JVI.20.2.441-445.1976
PMID:135847
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC355012/
Abstract

T4 heteroduplex heterozygotes are lost selectively after prolonged incubation of phage-infected Escherichia coli cells under nonreplicating conditions. The loss of heterozygosity occurs for four out of six rII sites tested and is not dependent upon T4 v gene function. The results are interpreted to indicate the existence of a base-specific system for the recognition of mismatched bases in intracellular DNA.

摘要

在非复制条件下对噬菌体感染的大肠杆菌细胞进行长时间培养后，T4异源双链杂合子会被选择性地丢失。在所测试的六个rII位点中的四个位点出现了杂合性的丧失，并且这并不依赖于T4 v基因的功能。这些结果被解释为表明细胞内DNA中存在一种识别错配碱基的碱基特异性系统。

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本文引用的文献

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Induction of pure mutant clones by repair of inactivating DNA alterations in phage t4.通过修复噬菌体T4中失活的DNA改变诱导纯突变克隆
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6
One way to do experiments on gene conversion? Transfection with heteroduplex SPP1 DNA.进行基因转换实验的一种方法是什么？用异源双链SPP1 DNA进行转染。
Mol Gen Genet. 1970;109(1):84-106. doi: 10.1007/BF00334048.
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Recombination in bacteriophage T4.噬菌体T4中的重组
Adv Genet. 1970;15:1-53. doi: 10.1016/s0065-2660(08)60070-x.
8
Dark repair of ultraviolet-irradiated deoxyribonucleic acid by bacteriophage T4: purification and characterization of a dimer-specific phage-induced endonuclease.噬菌体T4对紫外线照射的脱氧核糖核酸的暗修复：一种二聚体特异性噬菌体诱导的内切核酸酶的纯化与特性分析
J Bacteriol. 1971 May;106(2):500-7. doi: 10.1128/jb.106.2.500-507.1971.
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Marker-specific effects in genetic recombination.基因重组中的标记特异性效应。
J Mol Biol. 1970 Aug;51(3):633-55. doi: 10.1016/0022-2836(70)90013-6.
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Polynucleotide ligase in bacteriophage T4D recombination.噬菌体T4D重组中的多核苷酸连接酶
Genetics. 1972 Oct;72(2):187-203. doi: 10.1093/genetics/72.2.187.