Schou M, Goldfield M D, Weinstein M R, Villeneuve A
Br Med J. 1973 Apr 21;2(5859):135-6. doi: 10.1136/bmj.2.5859.135.
We have collected information about 118 children born to mothers who were given lithium treatment during the first trimester of pregnancy. The data show that the risk of teratogenic effects is lower than one might have expected from some of the studies carried out on rats and mice; they do not answer the question of whether or not lithium is teratogenic in man. The data were collected retrospectively and therefore overestimate rather than underestimate the risk of teratogenicity.
我们收集了118名母亲在孕期头三个月接受锂治疗后所生孩子的信息。数据显示，致畸效应的风险低于对大鼠和小鼠进行的一些研究所预期的；这些数据并未回答锂在人类中是否具有致畸性的问题。这些数据是回顾性收集的，因此高估而非低估了致畸风险。
