脱氧氟代-D-吡喃葡萄糖6-磷酸酯及其对酵母葡萄糖磷酸异构酶的影响。
The deoxyfluoro-D-glucopyranose 6-phosphates and their effect on yeast glucose phosphate isomerase.
作者信息
Bessell E M, Thomas P
出版信息
Biochem J. 1973 Jan;131(1):77-82. doi: 10.1042/bj1310077.
Abstract
- The deoxyfluoro-d-glucopyranose 6-phosphates were prepared from the corresponding deoxyfluoro-d-glucoses and ATP by using hexokinase. 2. 3-Deoxy-3-fluoro- and 4-deoxy-4-fluoro-d-glucose 6-phosphate were substrates for glucose phosphate isomerase, and in addition the products of this reaction, 3-deoxy-3-fluoro- and 4-deoxy-4-fluoro-d-fructose 6-phosphate respectively, were good substrates for phosphofructokinase. 3. Some C-2-substituted derivatives of d-glucose 6-phosphate were found to be competitive inhibitors of glucose phosphate isomerase. 4. The possible role of the hydroxyl groups in the binding of d-glucose 6-phopshate to glucose phosphate isomerase is discussed.
摘要
- 通过使用己糖激酶，由相应的脱氧氟-D-葡萄糖和ATP制备了6-磷酸脱氧氟-D-吡喃葡萄糖。2. 3-脱氧-3-氟-D-葡萄糖6-磷酸和4-脱氧-4-氟-D-葡萄糖6-磷酸是磷酸葡萄糖异构酶的底物，此外，该反应的产物，即分别为3-脱氧-3-氟-D-果糖6-磷酸和4-脱氧-4-氟-D-果糖6-磷酸，是磷酸果糖激酶的良好底物。3. 发现一些6-磷酸-D-葡萄糖的C-2-取代衍生物是磷酸葡萄糖异构酶的竞争性抑制剂。4. 讨论了羟基在6-磷酸-D-葡萄糖与磷酸葡萄糖异构酶结合中的可能作用。
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