Tavassoli M, Shaklai M
Br J Haematol. 1979 Mar;41(3):303-7. doi: 10.1111/j.1365-2141.1979.tb05863.x.
The nature of contact between endothelial cells in rat marrow sinuses was studied. Colloidal lanthanum permeated freely into the interendothelial space. Moreover, using freeze-fracture technique, we failed to show junctional structures where these endothelial cells came into contact. With thin sectioning electron microscopy, we observed occasional submembranous densities but the interendothelial distance measured 20 nm and no membrane fusion was seen. Absence of tight junctions between endothelial cells of marrow sinuses may serve a function in marrow cell egress by permitting these cells to slide over each other, thereby changing the luminal size. Within the fixed volume of marrow, an increase in luminal size results in displacement of haemopoietic cells into the lumen.
研究了大鼠骨髓窦内皮细胞之间的接触性质。胶体镧可自由渗透到内皮间隙。此外，使用冷冻断裂技术，我们未能在这些内皮细胞接触处显示出连接结构。通过超薄切片电子显微镜，我们偶尔观察到膜下致密物，但内皮间距离为20纳米，未见膜融合。骨髓窦内皮细胞间紧密连接的缺失可能通过允许这些细胞相互滑动从而改变管腔大小，在骨髓细胞逸出中发挥作用。在固定体积的骨髓内，管腔大小增加会导致造血细胞移入管腔。
