混合淋巴细胞反应作为克罗恩病患者淋巴细胞免疫能力的一种衡量方法。
Mixed-lymphocyte reaction as a measure of immunological competence of lymphocytes from patients with Crohn's disease.
作者信息
Richens E R, Williams M J, Gough K R, Ancill R J
出版信息
Gut. 1974 Jan;15(1):24-8. doi: 10.1136/gut.15.1.24.
Abstract
Peripheral blood lymphocytes from 12 patients with Crohn's disease and from a group of normal volunteers have been tested for transformation under stimulation of allogeneic cells in a mixed lymphocyte culture and by phytohaemagglutinin (PHA) in vitro. There was a significant depression of transformation in the mixed lymphocyte culture where lymphocytes from the Crohn's disease patients constituted the responding population. With PHA stimulation, no difference in transformation was seen between the patients and the control group. This is interpreted as indicating a depression in cellular immunity in Crohn's disease.
摘要
对12名克罗恩病患者及一组正常志愿者的外周血淋巴细胞进行了检测，观察其在混合淋巴细胞培养中同种异体细胞刺激下以及在体外经植物血凝素（PHA）刺激后的转化情况。在混合淋巴细胞培养中，当以克罗恩病患者的淋巴细胞作为反应细胞群时，其转化明显受到抑制。在PHA刺激下，患者组与对照组之间的转化未见差异。这被解释为表明克罗恩病患者存在细胞免疫抑制。
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Mixed-lymphocyte reaction as a measure of immunological competence of lymphocytes from patients with Crohn's disease.混合淋巴细胞反应作为克罗恩病患者淋巴细胞免疫能力的一种衡量方法。
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本文引用的文献
1
Mitogenic action of phytohaemagglutinin.植物血凝素的促有丝分裂作用。
Lancet. 1963 Aug 10;2(7302):305-6. doi: 10.1016/s0140-6736(63)90213-7.
2
Prednisolone inhibition of DNA synthesis by human lymphocytes induced in 1itro by phytohaemagglutinin.泼尼松龙对植物血凝素体外诱导的人淋巴细胞DNA合成的抑制作用。
Int Arch Allergy Appl Immunol. 1967;32(2):191-200. doi: 10.1159/000229927.
3
A study of Crohn's syndrome using tissue extracts and the Kveim and Mantoux tests.一项使用组织提取物以及克维姆试验和结核菌素试验对克罗恩综合征的研究。
Gut. 1965 Oct;6(5):503-5. doi: 10.1136/gut.6.5.503.
4
Cellular hypersensitivity to components of intestinal mucosa in ulcerative colitis and Crohn's disease.溃疡性结肠炎和克罗恩病中细胞对肠黏膜成分的超敏反应。
Gut. 1969 Aug;10(8):631-6. doi: 10.1136/gut.10.8.631.
5
Development of delayed hypersensitivity to dinitrochlorobenzene in patients with Crohn's disease.克罗恩病患者对二硝基氯苯迟发型超敏反应的发展
Gut. 1969 Jan;10(1):52-6. doi: 10.1136/gut.10.1.52.
6
7
In-vitro inhibition of leucocyte migration in Crohn's disease by a sarcoid spleen suspension.结节病脾脏悬液对克罗恩病白细胞迁移的体外抑制作用
Br Med J. 1971 Jul 17;3(5767):155-7. doi: 10.1136/bmj.3.5767.155.
8
Lymphocyte response to phytohemagglutinin in Hodgkin's disease.霍奇金病中淋巴细胞对植物血凝素的反应。
Am J Med. 1970 Jun;48(6):728-34. doi: 10.1016/s0002-9343(70)80008-0.
9
Leucocyte migration inhibition with Kveim antigen in Crohn's disease.克罗恩病中Kveim抗原所致的白细胞游走抑制
Clin Exp Immunol. 1971 Dec;9(6):707-11.
10
Short-term lymphocyte cultures in regional enteritis.局限性肠炎的短期淋巴细胞培养
Lancet. 1970 May 23;1(7656):1112. doi: 10.1016/s0140-6736(70)92776-5.
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