Richens E R, Williams M J, Gough K R, Ancill R J
Gut. 1974 Jan;15(1):24-8. doi: 10.1136/gut.15.1.24.
Peripheral blood lymphocytes from 12 patients with Crohn's disease and from a group of normal volunteers have been tested for transformation under stimulation of allogeneic cells in a mixed lymphocyte culture and by phytohaemagglutinin (PHA) in vitro. There was a significant depression of transformation in the mixed lymphocyte culture where lymphocytes from the Crohn's disease patients constituted the responding population. With PHA stimulation, no difference in transformation was seen between the patients and the control group. This is interpreted as indicating a depression in cellular immunity in Crohn's disease.
对12名克罗恩病患者及一组正常志愿者的外周血淋巴细胞进行了检测,观察其在混合淋巴细胞培养中同种异体细胞刺激下以及在体外经植物血凝素(PHA)刺激后的转化情况。在混合淋巴细胞培养中,当以克罗恩病患者的淋巴细胞作为反应细胞群时,其转化明显受到抑制。在PHA刺激下,患者组与对照组之间的转化未见差异。这被解释为表明克罗恩病患者存在细胞免疫抑制。