克罗恩病患者肠系膜淋巴结中的淋巴细胞转化
Lymphocyte transformation in the mesenteric lymph nodes of patients with Crohn's disease.
作者信息
Guillou P J, Brennan T G, Giles G R
出版信息
Gut. 1973 Jan;14(1):20-4. doi: 10.1136/gut.14.1.20.
Abstract
The response of lymphocytes from peripheral blood and mesenteric lymph nodes to stimulation with phytohaemagglutinin in vitro has been studied in eight patients suffering from active Crohn's disease. Patients with Crohn's disease exhibited reduced responses when compared with similar studies performed in control subjects. The impaired responses of circulating lymphocytes from these patients were marked on culture in autologous serum and were not improved by culture in homologous AB serum. Lymphocytes from lymph nodes directly draining diseased bowel exhibited lower responses than those from nodes at the root of the mesentery, which in turn were lower than those of circulating lymphocytes.
摘要
对8例活动性克罗恩病患者外周血和肠系膜淋巴结淋巴细胞在体外受植物血凝素刺激后的反应进行了研究。与在对照受试者中进行的类似研究相比，克罗恩病患者表现出反应降低。这些患者循环淋巴细胞的反应受损在自体血清中培养时很明显，在同源AB血清中培养也未得到改善。直接引流患病肠段的淋巴结中的淋巴细胞反应低于肠系膜根部淋巴结中的淋巴细胞，而肠系膜根部淋巴结中的淋巴细胞反应又低于循环淋巴细胞。
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