Tamaya T, Motoyama T, Ohono Y, Ide N, Tsurusaki T, Okada H
Fertil Steril. 1979 Apr;31(4):396-400. doi: 10.1016/s0015-0282(16)43935-x.
Steroid receptors in endometriosis and adenomyosis were investigated to clarify their clinical significance. The receptor levels were determined by Scatchard plot analysis (4 degrees C, by dextran-coated charcoal). In the cytosols of both tissues, the 17 beta-estradiol-estrogen receptor (ER) complex demonstrated a dissociation constant (Kd) of 4.5 x 10(-10) M; the Kd of the progesterone-progesterone receptor (PR) complex was 1.5 x 10(-9) M; and the Kd of the dihydrotestosterone-androgen receptor (AR) complex was 4.0 x 10(-10) M. Seven cases of ovarian endometriosis were studied. The ER and PR levels in endometriosis seemed to be lower than those in the corresponding normal endometrium. AR was also present. There was a suggestion that most endometriosis is least responsive to progestogens. Ten cases of adenomyosis were studied. Histologic dating revealed a delay in the most aberrant endometrial tissue in adenomyosis, as compared with dating of corresponding normal endometrial tissue. ER and AR were detected in all cases. PR was not detected in some cases and, when detected, the content seemed to be lower, possibly suggesting the delayed dating.
为阐明类固醇受体在子宫内膜异位症和子宫腺肌病中的临床意义，对其进行了研究。受体水平通过Scatchard作图分析（4℃，用葡聚糖包被活性炭）测定。在两种组织的胞质溶胶中，17β-雌二醇-雌激素受体（ER）复合物的解离常数（Kd）为4.5×10⁻¹⁰M；孕酮-孕酮受体（PR）复合物的Kd为1.5×10⁻⁹M；二氢睾酮-雄激素受体（AR）复合物的Kd为4.0×10⁻¹⁰M。研究了7例卵巢子宫内膜异位症病例。子宫内膜异位症中的ER和PR水平似乎低于相应正常子宫内膜中的水平。AR也存在。提示大多数子宫内膜异位症对孕激素反应最差。研究了10例子宫腺肌病病例。组织学分期显示，与相应正常子宫内膜组织的分期相比，子宫腺肌病中最异常的子宫内膜组织存在延迟。所有病例均检测到ER和AR。部分病例未检测到PR，而检测到PR时，其含量似乎较低，这可能提示分期延迟。
