Eldering G, Holwerda J, Baker J
J Bacteriol. 1966 May;91(5):1759-62. doi: 10.1128/jb.91.5.1759-1762.1966.
Eldering, Grace (Michigan Department of Public Health, Grand Rapids), Jack Holwerda, and Julia Baker. Bordetella pertussis culture having only species factor 1. J. Bacteriol. 91:1759-1762. 1966.-Preston's description of Bordetella pertussis 353-Z as a culture possessing only factor 1 was confirmed by agglutination and agglutinin-adsorption tests. The ld(50) values of this culture for mice inoculated by the intracerebral route were approximately the same as that of B. pertussis 18-323, the challenge culture in mouse potency tests of pertussis vaccine. In mouse protection tests, vaccine prepared with the factor 1 culture protected as well against challenge with B. pertussis 18-323, which has a broad antigenic pattern, as did vaccines made with cultures possessing factors 2, 3, 4, and 5 in addition to factor 1. When two groups of similarly immunized mice were challenged with 353-Z and 18-323, respectively, much lower ed(50) values were obtained with the animals challenged with 353-Z. This was true whether a factor 1 vaccine or a vaccine with factors 1, 2, 3, 4, and 5 was tested.
埃尔德林，格蕾丝（密歇根州公共卫生部，大急流城）、杰克·霍尔韦尔达和朱莉娅·贝克。仅具有种因子1的百日咳博德特氏菌培养物。《细菌学杂志》91:1759 - 1762。1966年。——通过凝集和凝集素吸附试验证实了普雷斯顿对百日咳博德特氏菌353 - Z作为仅具有因子1的培养物的描述。该培养物经脑内途径接种对小鼠的半数致死剂量（ld(50)）值与百日咳疫苗小鼠效力试验中的攻击培养物百日咳博德特氏菌18 - 323大致相同。在小鼠保护试验中，用因子1培养物制备的疫苗对具有广泛抗原模式的百日咳博德特氏菌18 - 323攻击的保护效果，与用除因子1外还具有因子2、3、4和5的培养物制备的疫苗相同。当两组免疫情况相似的小鼠分别用353 - Z和18 - 323攻击时，用353 - Z攻击的动物获得的半数有效剂量（ed(50)）值要低得多。无论测试的是因子1疫苗还是含有因子1、2、3、4和5的疫苗，都是如此。
