Ackermann W W, Wahl D
J Bacteriol. 1966 Oct;92(4):1051-4. doi: 10.1128/jb.92.4.1051-1054.1966.
Ackermann, W. W. (The University of Michigan, Ann Arbor), and D. Wahl. Programming of poliovirus inhibition of deoxyribonucleic acid synthesis in HeLa cells. J. Bacteriol. 92:1051-1054. 1966.-Deletion of arginine from a culture medium reduced the rate of deoxyribonucleic acid (DNA) synthesis in uninfected HeLa cells. The normal rate was promptly restored by addition of arginine. Deletion of arginine also prevented poliovirus from inhibiting DNA synthesis in HeLa cells. However, the inhibitory potential of the infection and the capacity of the host cell for stimulation with regard to DNA synthesis were both retained in arginine-depleted cells which were infected. Upon addition of arginine late in the infection, DNA synthesis was first stimulated and then inhibited.
阿克曼，W. W.（密歇根大学，安阿伯分校）和D. 瓦尔。脊髓灰质炎病毒对HeLa细胞中脱氧核糖核酸合成的抑制作用编程。《细菌学杂志》92:1051 - 1054。1966年。——从培养基中去除精氨酸会降低未感染的HeLa细胞中脱氧核糖核酸（DNA）的合成速率。添加精氨酸后，正常速率迅速恢复。去除精氨酸也能阻止脊髓灰质炎病毒抑制HeLa细胞中的DNA合成。然而，在感染的精氨酸缺乏细胞中，感染的抑制潜力和宿主细胞对DNA合成的刺激能力均得以保留。在感染后期添加精氨酸后，DNA合成先是受到刺激，然后被抑制。
