Urban M D, Lee P A, Kowarski A A, Plotnick L P, Migeon C J
J Clin Endocrinol Metab. 1979 May;48(5):732-5. doi: 10.1210/jcem-48-5-732.
Gonadotropin levels in isolated blood samples, integrated plasma concentrations (IC), and timed urinary collections have been compared in 5 males with delayed puberty and 7 normal adult males. There was a significant correlation between urinary levels in 24-h collection and those in each of four shorter timed collections for both LH and FSH. Similarly, 24-h integrated plasma concentration and 4-h (0800--1200 h) integrated plasma concentration obtained on 10 additional subjects showed significant correlation. The 4-h integrated plasma concentrations correlated with single blood samples or the mean of three samples obtained at 0800, 1200, and 1600 h. These 4-h plasma samples also correlated significantly with all urine collections for FSH but only with the 2200--0800 h urine collection for LH. The study suggests that LH and FSH levels in urine samples collected over several hours correlate with 24-h urinary excretion and that levels in single blood samples estimate the 24-h plasma integrated concentration.
对5名青春期延迟男性和7名正常成年男性的孤立血样中的促性腺激素水平、血浆综合浓度（IC）和定时尿样进行了比较。对于促黄体生成素（LH）和促卵泡生成素（FSH），24小时尿样收集量与四个较短定时收集量中的每一个之间存在显著相关性。同样，在另外10名受试者身上获得的24小时血浆综合浓度和4小时（08:00 - 12:00）血浆综合浓度显示出显著相关性。4小时血浆综合浓度与单个血样或在08:00、12:00和16:00获得的三个样本的平均值相关。这些4小时血浆样本与所有FSH尿样收集量也显著相关，但仅与LH的22:00 - 08:00尿样收集量相关。该研究表明，数小时内收集的尿样中的LH和FSH水平与24小时尿排泄量相关，并且单个血样中的水平可估计24小时血浆综合浓度。
