Khan A J, Evans H E, Glass L, Khan P, Chang C T, Nair S R
J Lab Clin Med. 1979 Feb;93(2):295-300.
Gentamicin and amikacin, administered in therapeutic doses to normal healthy adults, caused a transient decrease in chemotactic migration of their PMNs. In contrast, RM of leukocytes obtained from these individuals was increased significantly. The magnitude of these changes did not correlate with the serum antibiotic concentrations. Separate in vitro experiments with gentamicin, however, revealed an inverse dose-response relationship with chemotactic suppression. The mechanism(s) involved in modifications of these leukocyte functions is not well understood. These findings may be of clinical significance in patients, especially those with altered host defense mechanisms, who require therapy with these aminoglycoside antimicrobial agents.
对正常健康成年人给予治疗剂量的庆大霉素和阿米卡星后，其多形核中性粒细胞（PMN）的趋化迁移出现短暂下降。相比之下，从这些个体获得的白细胞随机迁移（RM）显著增加。这些变化的程度与血清抗生素浓度无关。然而，庆大霉素的体外单独实验显示，其与趋化抑制呈反向剂量反应关系。这些白细胞功能改变所涉及的机制尚不完全清楚。这些发现可能对需要使用这些氨基糖苷类抗菌药物进行治疗的患者具有临床意义，尤其是那些宿主防御机制改变的患者。
