Burns W H, Black P H
J Virol. 1968 Jun;2(6):606-9. doi: 10.1128/JVI.2.6.606-609.1968.
Clones of simian virus 40-transformed hamster kidney cells from which infectious virus could be recovered and clones which did not yield virus by the overlay technique were subjected to chemical (mitomycin C) induction and to co-cultivation and fusion studies with indicator cells. The results of these studies indicate that the complete viral genome is present in all clones tested but that considerable heterogeneity with respect to inducibility exists among the clones. It is suggested that differences either in the number of viral genomes per transformed cell or in the status of the viral genome in transformed cells exist among the various clones. Furthermore, the inducibility of the clones may be correlated with their malignant potential.
从可回收感染性病毒的猴病毒40转化的仓鼠肾细胞克隆以及通过覆盖技术未产生病毒的克隆，进行化学（丝裂霉素C）诱导以及与指示细胞的共培养和融合研究。这些研究结果表明，在所有测试的克隆中都存在完整的病毒基因组，但各克隆之间在诱导性方面存在相当大的异质性。有人提出，不同克隆之间要么每个转化细胞中的病毒基因组数量不同，要么转化细胞中病毒基因组的状态不同。此外，克隆的诱导性可能与其恶性潜能相关。
