合成双链RNA（聚肌苷酸和聚胞苷酸）在小鼠中诱导产生的口蹄疫病毒抑制作用。
Foot-and-mouth disease virus inhibition induced in mice by synthetic double-stranded RNA (polyriboinosinic and polyribocytidylic acids).
作者信息
Richmond J Y, Hamilton L D
出版信息
Proc Natl Acad Sci U S A. 1969 Sep;64(1):81-6. doi: 10.1073/pnas.64.1.81.
Abstract
Synthetic 2-stranded RNA-a helical complex formed by duplexing homopolymers of polyriboinosinic and polyribocytidylic acids (poly I:C)-induced host resistance to foot-and-mouth disease virus when microgram quantities were injected into mice. There was a graded response as shown by titrations of polynucleotide complex or virus. Protection was effective for >48 hours after a single injection of polynucleotide complex. Survival and serum interferon titers were directly related.
摘要
由聚肌苷酸和聚胞苷酸（聚 I:C）的同聚物双链形成的合成双链 RNA - α 螺旋复合物，当将微克量注射到小鼠体内时，可诱导宿主对口蹄疫病毒产生抗性。如对多核苷酸复合物或病毒进行滴定所示，存在分级反应。单次注射多核苷酸复合物后，保护作用可持续超过 48 小时。存活率和血清干扰素滴度直接相关。
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Foot-and-mouth disease virus inhibition induced in mice by synthetic double-stranded RNA (polyriboinosinic and polyribocytidylic acids).合成双链RNA（聚肌苷酸和聚胞苷酸）在小鼠中诱导产生的口蹄疫病毒抑制作用。
Proc Natl Acad Sci U S A. 1969 Sep;64(1):81-6. doi: 10.1073/pnas.64.1.81.
2
Induction of interferon by preparations of synthetic single-stranded RNA.合成单链RNA制剂诱导干扰素的产生。
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[Action of polyriboinosinic acid-polyribocytidylic acid bicatenary complex (poly I:C) on infection caused by various viruses in mice].[聚肌苷酸-聚胞苷酸双链复合物（聚肌苷酸:聚胞苷酸）对小鼠多种病毒感染的作用]
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