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The effect of pH on the characteristics of the binding of nicotinamide-adenine dinucleotide by nicotinamide-adenine dinucleotide-specific isocitrate dehydrogenase from pea mitochondria.pH对豌豆线粒体中烟酰胺腺嘌呤二核苷酸特异性异柠檬酸脱氢酶与烟酰胺腺嘌呤二核苷酸结合特性的影响。
Biochem J. 1970 Mar;116(5):819-24. doi: 10.1042/bj1160819.
2
The effects of pH and citrate on the activity of nicotinamideA-denine dinucleotide-specific isocitrate dehydrogenase from pea mitochondria.pH值和柠檬酸盐对豌豆线粒体中烟酰胺腺嘌呤二核苷酸特异性异柠檬酸脱氢酶活性的影响。
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3
The proton-translocating nicotinamide-adenine dinucleotide (phosphate) transhydrogenase of rat liver mitochondria.大鼠肝脏线粒体的质子转运型烟酰胺腺嘌呤二核苷酸（磷酸）转氢酶
Biochem J. 1973 Mar;132(3):571-85. doi: 10.1042/bj1320571.
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Nicotinamide-adenine dinucleotide-specific isocitrate dehydrogenase from pea mitochondria. Purification and properties.豌豆线粒体中烟酰胺腺嘌呤二核苷酸特异性异柠檬酸脱氢酶。纯化及特性
Biochem J. 1967 Nov;105(2):729-34. doi: 10.1042/bj1050729.
5
Nicotinamide-adenine dinucleotide-specific isocitrate dehydrogenase from pea mitochondria.来自豌豆线粒体的烟酰胺腺嘌呤二核苷酸特异性异柠檬酸脱氢酶。
Biochem J. 1967 Sep;104(3):49P.
6
Affinity chromatography of yeast nicotinamide-adenine dinucleotide-specific isocitrate dehydrogenase on immobilized nicotinamide-adenine dinucleotide. Effects of ligands.酵母烟酰胺腺嘌呤二核苷酸特异性异柠檬酸脱氢酶在固定化烟酰胺腺嘌呤二核苷酸上的亲和层析。配体的影响。
Ital J Biochem. 1977 Nov-Dec;26(6):486-96.
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Purification and properties of a soluble nicotinamide adenine dinucleotide-linked isocitrate dehydrogenase from Crithidia fasciculata.来自纤细短膜虫的一种可溶性烟酰胺腺嘌呤二核苷酸连接的异柠檬酸脱氢酶的纯化及性质
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8
Regulation of NAD+-linked isocitrate dehydrogenase and 2-oxoglutarate dehydrogenase by Ca2+ ions within toluene-permeabilized rat heart mitochondria. Interactions with regulation by adenine nucleotides and NADH/NAD+ ratios.甲苯通透化大鼠心脏线粒体中Ca2+离子对NAD+连接的异柠檬酸脱氢酶和2-氧代戊二酸脱氢酶的调节作用。与腺嘌呤核苷酸调节及NADH/NAD+比值的相互作用。
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9
The role of nicotinamide-adenine dinucleotide phosphate-dependent malate dehydrogenase and isocitrate dehydrogenase in the supply of reduced nicotinamide-adenine dinucleotide phosphate for steroidogenesis in the superovulated rat ovary.烟酰胺腺嘌呤二核苷酸磷酸依赖性苹果酸脱氢酶和异柠檬酸脱氢酶在超排卵大鼠卵巢类固醇生成中提供还原型烟酰胺腺嘌呤二核苷酸磷酸的作用。
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Effect of pH on the inhibition of the nicotinamide-adenine dinucleotide-specific isocitrate dehydrogenase from baker's yeast by anions.pH对阴离子抑制面包酵母烟酰胺腺嘌呤二核苷酸特异性异柠檬酸脱氢酶的影响。
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1
NADP-Utilizing Enzymes in the Matrix of Plant Mitochondria.植物线粒体基质中利用NADP的酶
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2
Nicotinamide adenine dinucleotide phosphate-specific isocitrate dehydrogenase from a higher plant. Isolation and charactertization.来自高等植物的烟酰胺腺嘌呤二核苷酸磷酸特异性异柠檬酸脱氢酶。分离与特性鉴定。
Plant Physiol. 1971 Jan;47(1):43-7. doi: 10.1104/pp.47.1.43.

本文引用的文献

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The Combinations of Haemoglobin with Oxygen and with Carbon Monoxide. I.血红蛋白与氧气及一氧化碳的结合。I.
Biochem J. 1913 Oct;7(5):471-80. doi: 10.1042/bj0070471.
2
KINETICS OF REGULATORY ENZYMES. KINETIC ORDER OF THE YEAST DIPHOSPHOPYRIDINE NUCLEOTIDE ISOCITRATE DEHYDROGENASE REACTION AND A MODEL FOR THE REACTION.调节酶的动力学。酵母二磷酸吡啶核苷酸异柠檬酸脱氢酶反应的动力学级数及反应模型。
J Biol Chem. 1965 Jun;240:2682-90.
3
ALLOSTERIC ACTIVATION OF NICOTINAMIDE-ADENINE DINUCLEOTIDE SPECIFIC ISOCITRATE DEHYDROGENASE OF NEUROSPORA.粗糙脉孢菌烟酰胺腺嘌呤二核苷酸特异性异柠檬酸脱氢酶的变构激活作用
Biochim Biophys Acta. 1965 Jan;96:28-44. doi: 10.1016/0005-2787(65)90606-4.
4
DPN-SPECIFIC ISOCITRATE-DEHYDROGENASE OF MITOCHONDRIA. II. PH-DEPENDENCE OF THE KINETICS AND THE MECHANISM OF ACTIVATION.线粒体中糖尿病周围神经病变特异性异柠檬酸脱氢酶。II. 动力学的pH依赖性及激活机制
Biochem Z. 1965 Feb 8;341:199-223.
5
The effect of pH on the affinities of enzymes for substrates and inhibitors.pH 对酶与底物及抑制剂亲和力的影响。
Biochem J. 1953 Aug;55(1):161-70. doi: 10.1042/bj0550161.
6
Comparison of experimental binding data and theoretical models in proteins containing subunits.含亚基蛋白质中实验结合数据与理论模型的比较。
Biochemistry. 1966 Jan;5(1):365-85. doi: 10.1021/bi00865a047.
7
The effects of pH and citrate on the activity of nicotinamideA-denine dinucleotide-specific isocitrate dehydrogenase from pea mitochondria.pH值和柠檬酸盐对豌豆线粒体中烟酰胺腺嘌呤二核苷酸特异性异柠檬酸脱氢酶活性的影响。
Biochem J. 1969 Aug;113(5):813-20. doi: 10.1042/bj1130813.
8
Regulatory properties of a plant NAD: isocitrate dehydrogenase. The effect of inorganic ions.一种植物烟酰胺腺嘌呤二核苷酸：异柠檬酸脱氢酶的调节特性。无机离子的影响。
Eur J Biochem. 1969 Jan;7(2):153-8. doi: 10.1111/j.1432-1033.1969.tb19586.x.
9
Nicotinamide-adenine dinucleotide-specific isocitrate dehydrogenase from pea mitochondria. Purification and properties.豌豆线粒体中烟酰胺腺嘌呤二核苷酸特异性异柠檬酸脱氢酶。纯化及特性
Biochem J. 1967 Nov;105(2):729-34. doi: 10.1042/bj1050729.

pH对豌豆线粒体中烟酰胺腺嘌呤二核苷酸特异性异柠檬酸脱氢酶与烟酰胺腺嘌呤二核苷酸结合特性的影响。

The effect of pH on the characteristics of the binding of nicotinamide-adenine dinucleotide by nicotinamide-adenine dinucleotide-specific isocitrate dehydrogenase from pea mitochondria.

作者信息

Cox G F, Davies D D

出版信息

Biochem J. 1970 Mar;116(5):819-24. doi: 10.1042/bj1160819.

DOI:10.1042/bj1160819
PMID:4315048
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1185504/
Abstract
  1. The effect of pH on the V(max.) and concentration of NAD(+) at half-maximum velocity at a constant isocitrate concentration was examined, and the results were related to the requirements for binding of H(+) ions to the enzyme. 2. The effect of varying the NAD(+) concentration on the pH optimum with constant isocitrate concentration was studied. 3. A comparison has been made between the effect of isocitrate concentration on the characteristics of binding of NAD(+) and the effect of NAD(+) concentration on the characteristics of isocitrate binding at three different pH values. 4. The mechanistic and metabolic significance of these studies is considered.
摘要
  1. 在异柠檬酸浓度恒定的情况下，研究了pH对最大反应速度（V(max.)）以及达到最大反应速度一半时NAD(+)浓度的影响，并将结果与H(+)离子与酶结合的需求相关联。2. 在异柠檬酸浓度恒定的情况下，研究了改变NAD(+)浓度对最适pH的影响。3. 比较了在三种不同pH值下，异柠檬酸浓度对NAD(+)结合特性的影响以及NAD(+)浓度对异柠檬酸结合特性的影响。4. 考虑了这些研究的机制和代谢意义。