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鼠伤寒沙门氏菌中的UGA无义突变。

UGA nonsense mutations in Salmonella typhimurium.

作者信息

Roth J R

出版信息

J Bacteriol. 1970 May;102(2):467-75. doi: 10.1128/jb.102.2.467-475.1970.

DOI:10.1128/jb.102.2.467-475.1970
PMID:4315894
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC247572/
Abstract

Salmonella typhimurium strain LT-2 carries a weak UGA suppressor activity. This activity prevents the detection of some UGA mutants as auxotrophs and probably accounts for the rarity of his UGA mutants in this strain. A selection method is described which permits the isolation of these rare his UGA mutants. Map distribution of his UGA mutations is normal, and their polarity effects are indistinguishable from the polarity effects of amber and ochre mutations at similar locations. Isolation and properties of a prototrophic his UGA mutant are described. UGA mutants are common among lac mutants isolated from Salmonella strains carrying an F'lac episome. Apparently the suppressor activity is insufficient to prevent detection of lac UGA mutants. It is not yet clear whether the suppressor activity plays an important role in normal cell physiology.

摘要

鼠伤寒沙门氏菌LT-2菌株具有微弱的UGA抑制活性。这种活性会阻止一些UGA突变体被检测为营养缺陷型，这可能就是该菌株中his UGA突变体稀少的原因。本文描述了一种选择方法，该方法可用于分离这些罕见的his UGA突变体。his UGA突变的图谱分布正常，其极性效应与相似位置的琥珀突变和赭石突变的极性效应无法区分。本文还描述了一个原养型his UGA突变体的分离及其特性。UGA突变体在从携带F'lac附加体的沙门氏菌菌株中分离出的lac突变体中很常见。显然，这种抑制活性不足以阻止lac UGA突变体被检测到。目前尚不清楚这种抑制活性在正常细胞生理学中是否起重要作用。

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