Lehner T
Br J Cancer. 1970 Sep;24(3):442-6. doi: 10.1038/bjc.1970.52.
The lymphocyte transformation test was performed with autologous saline homogenates of leukoplakia. A negative correlation was established (P<0.05) between the (14)C thymidine uptake of lymphocytes in vitro and the non-pyroninophilic mononuclear cell infiltration in biopsies. A depression of lymphocyte transformation was revealed in patients with carcinoma or carcinoma in situ and some with epithelial atypia, as compared with those showing only hyperkeratosis and to a less extent those with acanthosis. A corresponding depression was not found when lymphocytes were stimulated with phytohaemagglutinin, Candida albicans or Herpes simplex antigens. The Pyroninophilic cell count was raised in biopsies with carcinoma or carcinoma in situ and in some with epithelial atypia or acanthosis. These result suggest that in leukoplakia the carcinomatous transformation may be associated with some immunological changes.
采用白斑自体生理盐水匀浆进行淋巴细胞转化试验。体外淋巴细胞对(14)C胸苷的摄取与活检中嗜派洛宁单核细胞浸润之间呈负相关(P<0.05)。与仅表现为角化过度的患者相比,原位癌或癌患者以及部分上皮异型增生患者的淋巴细胞转化受到抑制,棘皮症患者的淋巴细胞转化抑制程度较轻。当用植物血凝素、白色念珠菌或单纯疱疹抗原刺激淋巴细胞时,未发现相应的抑制作用。在原位癌或癌以及部分上皮异型增生或棘皮症的活检中,嗜派洛宁细胞计数升高。这些结果表明,在白斑中,癌变可能与某些免疫变化有关。