癌组织及癌前病变中针对1型疱疹病毒的细胞介导免疫。
Cell mediated immunity to herpesvirus type 1 in carcinoma and pre-cancerous lesions.
作者信息
Lehner T, Shillitoe E J, Wilton J M, Ivanyi L
出版信息
Br J Cancer Suppl. 1973 Aug;1:128-34.
The response of lymphocytes to type 1 (HVH1), and phytohaemagglutinin was studied sequentially over a period of 3 years in patients with leukoplakia and carcinoma. In the keratosis-acanthosis group of leukoplakia there was a significant decrease in stimulation of lymphocytes by HVH1, in contrast to epithelial atypia which yielded both increased stimulation indices and macrophage migration inhibition to HVH1. Non-specific depressed cell mediated immune responses were found in carcinoma. Sequential data revealed major fluctuations in stimulation indices to HVH1 during the course of epithelial atypia and a fall in the stimulation indices from > 7 to < 2 was associated with carcinomatous transformation. These changes argue in favour of participation of HVH1 in the pathogenesis of some leukoplakias, and the development of epithelial atypia with subsequent carcinoma might be a function of the cell mediated immune responses to the virus.
在3年的时间里，对白斑和癌症患者淋巴细胞对1型人乳头瘤病毒（HVH1）和植物血凝素的反应进行了连续研究。在白斑的角化棘皮瘤组中，HVH1对淋巴细胞的刺激显著降低，与之形成对比的是上皮异型增生，其对HVH1的刺激指数增加且巨噬细胞移动抑制增强。在癌症中发现了非特异性的细胞介导免疫反应降低。连续数据显示，在上皮异型增生过程中，对HVH1的刺激指数有较大波动，刺激指数从>7降至<2与癌变相关。这些变化表明HVH1参与了某些白斑的发病机制，上皮异型增生伴随后续癌变的发展可能是细胞介导的针对该病毒免疫反应的结果。
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