促肾上腺皮质激素和去甘氨酰胺9-赖氨酸加压素对嘌呤霉素所致记忆抑制的作用。
Effect of corticotropin and desglycinamide 9 -lysine vasopressin on suppression of memory by puromycin.
作者信息
Lande S, Flexner J B, Flexner L B
出版信息
Proc Natl Acad Sci U S A. 1972 Mar;69(3):558-60. doi: 10.1073/pnas.69.3.558.
Abstract
The puromycin-induced blockade of expression of maze learning in mice can be prevented by subcutaneous administration of "Purified Cortrophin Gel" up to 3 days prior to training. A similar protective effect was not found when highly purified corticotropin was tested, but was observed after administration of desglycinamide(9)-lysine vasopressin. It appears that pressorpeptides are more potent protective agents than corticotropin when administered subcutaneously, and that vasopressin contamination of the commercial preparation was probably responsible for the protective effects previously reported. These experiments suggest that vasopressin and its congeners modify memory consolidation in such a way that the "expression" of memory becomes insensitive to puromycin.
摘要
在训练前3天内皮下注射“纯化促肾上腺皮质激素凝胶”，可防止嘌呤霉素诱导的小鼠迷宫学习能力表达受阻。对高纯度促肾上腺皮质激素进行测试时未发现类似的保护作用，但在给予去甘氨酰胺（9）-赖氨酸加压素后观察到了这种作用。皮下给药时，似乎升压肽作为保护剂比促肾上腺皮质激素更有效，而且商业制剂中加压素的污染可能是先前报道的保护作用的原因。这些实验表明，加压素及其同系物以这样一种方式改变记忆巩固，即记忆的“表达”对嘌呤霉素变得不敏感。
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本文引用的文献
1
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Science. 1966 Jul 15;153(3733):318-20. doi: 10.1126/science.153.3733.318.
2
Memory in mice as affected by intracerebral puromycin.脑内嘌呤霉素对小鼠记忆的影响
Science. 1963 Jul 5;141(3575):57-9. doi: 10.1126/science.141.3575.57.
3
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Science. 1967 Mar 17;155(3768):1377-83. doi: 10.1126/science.155.3768.1377.
4
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Fed Proc. 1971 Jul-Aug;30(4):1378-82.
5
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J Biol Chem. 1971 Apr 10;246(7):2058-62.
6
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Proc Natl Acad Sci U S A. 1967 Jun;57(6):1651-4. doi: 10.1073/pnas.57.6.1651.
7
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8
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