Trelstad R L, Coulombre A J
J Cell Biol. 1971 Sep;50(3):840-58. doi: 10.1083/jcb.50.3.840.
The embryonic chick corneal epithelium produces a highly structured acellular matrix beneath its basal surface during early development. This matrix, which contains collagen, serves as a morphogenetic template for subsequent stromal development in that the three-dimensional architecture of the adult corneal stroma is initially established, in miniature, in this epithelially derived connective tissue. Examination of the early corneal epithelium and matrix in both the light and electron microscope suggests that self assembly of the matrix may be one of several important factors in the morphogenesis of this early connective tissue.
胚胎期鸡的角膜上皮在早期发育过程中,会在其基底面下产生一种高度结构化的无细胞基质。这种含有胶原蛋白的基质,作为后续基质发育的形态发生模板,因为成年角膜基质的三维结构最初是以微型形式在这种上皮衍生的结缔组织中建立的。用光镜和电镜对早期角膜上皮和基质进行检查表明,基质的自我组装可能是这种早期结缔组织形态发生的几个重要因素之一。