优势突变的富集筛选：组氨酸操纵子突变
Enriched selection of dominant mutations: histidine operator mutations.
作者信息
Chang G W, Straus D, Ames B N
出版信息
J Bacteriol. 1971 Aug;107(2):578-9. doi: 10.1128/jb.107.2.578-579.1971.
Abstract
In the course of selection of bacteria with derepressed levels of histidine biosynthetic enzymes, it was found that when mutagen-treated cells were spread on a selective medium without allowing intervening growth to occur, the frequency of operator mutants obtained was dramatically increased. This may be useful as a general enrichment for operator or other dominant mutations.
摘要
在筛选组氨酸生物合成酶水平去阻遏的细菌的过程中，发现当将经诱变处理的细胞铺在选择性培养基上而不允许中间生长发生时，获得的操纵基因突变体的频率会显著增加。这对于操纵子或其他显性突变的一般富集可能是有用的。
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