多瘤病毒感染的小鼠细胞中DNA聚合酶的诱导需要转录和翻译。
Induction of DNA polymerase in polyoma virus-infected mouse cells requires transcription and translation.
作者信息
Wintersberger E, Wintersberger U
出版信息
J Virol. 1976 Aug;19(2):291-5. doi: 10.1128/JVI.19.2.291-295.1976.
Abstract
The induction of DNA polymerase activity and of DNA synthesis in polyoma virus-infected mouse kidney cells is inhibited by actinomycin D and cycloheximide, even in cells that are already T-antigen positive. This indicates that the induction of the DNA-synthesizing apparatus requires transcription and translation. The increase in cellular DNA polymerase activity and in the DNA synthesizing capacity follows the appearance of T-antigen only after a characteristic lag period of several hours.
摘要
在多瘤病毒感染的小鼠肾细胞中，即使是已经呈T抗原阳性的细胞，放线菌素D和环己酰亚胺也会抑制DNA聚合酶活性的诱导和DNA合成。这表明DNA合成装置的诱导需要转录和翻译。细胞DNA聚合酶活性和DNA合成能力的增加仅在数小时的特征性延迟期后才跟随T抗原的出现。
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