多瘤病毒感染的小鼠细胞中DNA聚合酶的诱导需要转录和翻译。
Induction of DNA polymerase in polyoma virus-infected mouse cells requires transcription and translation.
作者信息
Wintersberger E, Wintersberger U
出版信息
J Virol. 1976 Aug;19(2):291-5. doi: 10.1128/JVI.19.2.291-295.1976.
Abstract
The induction of DNA polymerase activity and of DNA synthesis in polyoma virus-infected mouse kidney cells is inhibited by actinomycin D and cycloheximide, even in cells that are already T-antigen positive. This indicates that the induction of the DNA-synthesizing apparatus requires transcription and translation. The increase in cellular DNA polymerase activity and in the DNA synthesizing capacity follows the appearance of T-antigen only after a characteristic lag period of several hours.
摘要
在多瘤病毒感染的小鼠肾细胞中，即使是已经呈T抗原阳性的细胞，放线菌素D和环己酰亚胺也会抑制DNA聚合酶活性的诱导和DNA合成。这表明DNA合成装置的诱导需要转录和翻译。细胞DNA聚合酶活性和DNA合成能力的增加仅在数小时的特征性延迟期后才跟随T抗原的出现。
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本文引用的文献
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DEOXYTHYMIDYLATE SYNTHETASE AND DEOXYTHYMIDINE KINASE ACTIVITIES OF VIRUS-INFECTED ANIMAL CELLS.病毒感染动物细胞的脱氧胸苷酸合成酶和脱氧胸苷激酶活性
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Polynucleotide ligase activity in cells infected with simian virus 40, polyoma virus, or vaccinia virus.感染猿猴病毒40、多瘤病毒或牛痘病毒的细胞中的多核苷酸连接酶活性。
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A study on the mechanism of polyoma-induced activation of the cellular DNA-synthesizing apparatus. Synchronization by FUdR of virus-induced DNA synthesis.多瘤病毒诱导细胞DNA合成装置激活机制的研究。用氟尿苷对病毒诱导的DNA合成进行同步化处理。
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