抗利尿激素及相关肽：训练前或训练后处理对嘌呤霉素所致遗忘症的影响。

ADH and related peptides: effect of pre- or posttraining treatment on puromycin amnesia.

作者信息

Flexner J B, Flexner L B, Walter R, Hoffman P L

出版信息

Pharmacol Biochem Behav. 1978 Jan;8(1):93-5. doi: 10.1016/0091-3057(78)90129-6.

Abstract

The peptide Z-Pro-Leu-Gly-NH2 attenuated puromycin-induced amnesia in mice when administered 5 days prior to training, while arginine vasopressin, lysine vasopressin and cyclo(Leu-Gly), were effective when given 24 hr before training. The activity of all peptides to inhibit puromycin-induced amnesia decreased as the interval after training and before peptide administration increased, suggesting that the peptides influence memory processes rather than generalized arousal mechanisms.

摘要

肽Z-Pro-Leu-Gly-NH2在训练前5天给药时可减轻嘌呤霉素诱导的小鼠失忆，而精氨酸加压素、赖氨酸加压素和环（亮氨酸-甘氨酸）在训练前24小时给药时有效。随着训练后至肽给药前的时间间隔增加，所有肽抑制嘌呤霉素诱导失忆的活性均降低，这表明这些肽影响记忆过程而非一般的觉醒机制。