McDonald J T, Margen S
Am J Clin Nutr. 1979 Apr;32(4):823-33. doi: 10.1093/ajcn/32.4.823.
A metabolic balance study was performed to determine the effects of wine vs ethanol on absorption of various elements. Calcium, phosphorus, and magnesium data are reported here. The study was divided into four 18-day experimental periods during which six healthy males were given, in random order, 1 liter/day of one of the following test beverages: Zinfandel wine (9.3% w/v alcohol); delacholized Zinfandel wine; pure ethanol (9.3% w/v aqueous solution); or deionized water. The test beverages were administered along with a controlled isocaloric diet in four equal feedings over a 12-hr period. Each man served as his own control. Urinary calcium and magnesium did not change appreciably during the course of the study. Urinary phosphorous, however, was significantly greater during wine and ethanol administration, suggesting that alcohol may affect the metabolism or renal tubular reabsorption of this element. Despite considerable individual variation, the data showed that wine and dealcoholized wine enhanced absorption of calcium, phosphorus, and magnesium. This apparently was due to an effect of one or more of the many congeners present in wine and absent in a calorically equivalent amount of pure ethanol. The natural acidity of wine also may have played a role in creating a more favorable intraluminal environment for absorption. There was no significant difference between experimental periods in serum calcium, phosphorus, and magnesium.
进行了一项代谢平衡研究，以确定葡萄酒与乙醇对各种元素吸收的影响。本文报告了钙、磷和镁的数据。该研究分为四个为期18天的实验阶段，在此期间，六名健康男性被随机给予以下测试饮料之一，每天1升：仙粉黛葡萄酒（酒精含量9.3%，重量/体积）；脱醇仙粉黛葡萄酒；纯乙醇（9.3%，重量/体积水溶液）；或去离子水。测试饮料与控制热量的饮食一起，在12小时内分四次等量喂食。每个男性都作为自己的对照。在研究过程中，尿钙和镁没有明显变化。然而，在饮用葡萄酒和乙醇期间，尿磷显著增加，这表明酒精可能会影响该元素的代谢或肾小管重吸收。尽管个体差异很大，但数据显示葡萄酒和脱醇葡萄酒可增强钙、磷和镁的吸收。这显然是由于葡萄酒中存在而等量纯乙醇中不存在的一种或多种同系物的作用。葡萄酒的天然酸度也可能在为吸收创造更有利的腔内环境方面发挥了作用。各实验阶段的血清钙、磷和镁之间没有显著差异。
