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Increased prothrombin time and metabolic changes with high serum aluminum levels following long-term exposure to Bayer-process alumina.长期接触拜耳法氧化铝后,凝血酶原时间延长以及血清铝水平升高伴随代谢变化。
Can Med Assoc J. 1971 Dec 18;105(12):1297-9 passim.
2
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[Serum aluminum and normal kidney function: effect of age and environmental exposure to aluminum].[血清铝与正常肾功能:年龄及环境铝暴露的影响]
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引用本文的文献

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Aluminum in the environment and human health.环境中的铝与人类健康。
Environ Health Perspect. 1974 Aug;8:3-95. doi: 10.1289/ehp.7483.
3
Metabolism and possible health effects of aluminum.铝的代谢及对健康可能产生的影响。
Environ Health Perspect. 1986 Mar;65:363-441. doi: 10.1289/ehp.8665363.
4
[The analyses of aluminum in serum and urine for monitoring of exposed persons (author's transl)].[血清和尿液中铝的分析用于监测接触者(作者译)]
Int Arch Occup Environ Health. 1976 Oct 21;38(1):1-17. doi: 10.1007/BF00378316.

本文引用的文献

1
The biochemistry of aluminium: Effect of aluminium on growth and reproduction in the rat. IV. The occurrence of aluminium in the thyroid. V. Intestinal absorption of aluminium in the rabbit.铝的生物化学:铝对大鼠生长和繁殖的影响。IV. 甲状腺中铝的存在情况。V. 家兔对铝的肠道吸收。
Biochem J. 1932;26(3):833-45. doi: 10.1042/bj0260833.
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The biochemistry of aluminium: Excretion and absorption of aluminium in the pig.铝的生物化学:猪体内铝的排泄与吸收
Biochem J. 1930;24(5):1433-41. doi: 10.1042/bj0241433.
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The effect of beryllium on certain enzymes.铍对某些酶的影响。
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Variability in the metal content of human organs.
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OSTEOMALACIA AND DEBILITY RESULTING FROM PHOSPHORUS DEPLETION.磷缺乏导致的骨质软化症与身体虚弱
Trans Assoc Am Physicians. 1964;77:281-95.
6
TRACE METAL LEVELS IN HUMAN SERUM AND BLOOD.人体血清和血液中的痕量金属水平
Arch Environ Health. 1964 Jan;8:52-7. doi: 10.1080/00039896.1964.10663631.
7
Trace elements in human tissue. II. Adult subjects from the United States.人体组织中的微量元素。II. 来自美国的成年受试者。
Health Phys. 1963 Feb;9:103-45. doi: 10.1097/00004032-196302000-00002.
8
Diminished blood ATP levels induced in the chick by dietary aluminum hydroxide gel.饮食中的氢氧化铝凝胶导致雏鸡血液中三磷酸腺苷(ATP)水平降低。
J Appl Physiol. 1959 Mar;14(2):259-60. doi: 10.1152/jappl.1959.14.2.259.
9
Estimation of plasma phosphatase by determination of hydrolysed phenol with amino-antipyrine.通过用氨基安替比林测定水解苯酚来估算血浆磷酸酶。
J Clin Pathol. 1954 Nov;7(4):322-6. doi: 10.1136/jcp.7.4.322.
10
[The problem of energy transport within living cells].[活细胞内的能量传输问题]
Adv Enzymol Relat Subj Biochem. 1953;14:1-48.

长期接触拜耳法氧化铝后,凝血酶原时间延长以及血清铝水平升高伴随代谢变化。

Increased prothrombin time and metabolic changes with high serum aluminum levels following long-term exposure to Bayer-process alumina.

作者信息

Waldron-Edward D, Chan P, Skoryna S C

出版信息

Can Med Assoc J. 1971 Dec 18;105(12):1297-9 passim.

PMID:4338426
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1931331/
Abstract

Serum aluminum levels twice to three times those in controls were found in 30 of 36 workers in a factory in an atmosphere of alumina dust. Inorganic phosphate and total alkaline phosphatase levels were within normal range, with no clinical evidence of phosphate depletion syndrome. Serum intestinal alkaline phosphatase, acid phosphatase and adenosine triphosphate levels were significantly reduced in the group with high levels of aluminum. The finding that the mean prothrombin time was significantly prolonged is of particular interest with respect to beneficial antithrombogenic effect.

摘要

在一家存在氧化铝粉尘的工厂中,36名工人中有30人的血清铝水平是对照组的两到三倍。无机磷酸盐和总碱性磷酸酶水平在正常范围内,没有磷酸盐消耗综合征的临床证据。铝水平高的组中,血清肠碱性磷酸酶、酸性磷酸酶和三磷酸腺苷水平显著降低。凝血酶原时间均值显著延长这一发现,就有益的抗血栓形成作用而言尤其值得关注。