长期接触拜耳法氧化铝后，凝血酶原时间延长以及血清铝水平升高伴随代谢变化。
Increased prothrombin time and metabolic changes with high serum aluminum levels following long-term exposure to Bayer-process alumina.
作者信息
Waldron-Edward D, Chan P, Skoryna S C
出版信息
Can Med Assoc J. 1971 Dec 18;105(12):1297-9 passim.
Abstract
Serum aluminum levels twice to three times those in controls were found in 30 of 36 workers in a factory in an atmosphere of alumina dust. Inorganic phosphate and total alkaline phosphatase levels were within normal range, with no clinical evidence of phosphate depletion syndrome. Serum intestinal alkaline phosphatase, acid phosphatase and adenosine triphosphate levels were significantly reduced in the group with high levels of aluminum. The finding that the mean prothrombin time was significantly prolonged is of particular interest with respect to beneficial antithrombogenic effect.
摘要
在一家存在氧化铝粉尘的工厂中，36名工人中有30人的血清铝水平是对照组的两到三倍。无机磷酸盐和总碱性磷酸酶水平在正常范围内，没有磷酸盐消耗综合征的临床证据。铝水平高的组中，血清肠碱性磷酸酶、酸性磷酸酶和三磷酸腺苷水平显著降低。凝血酶原时间均值显著延长这一发现，就有益的抗血栓形成作用而言尤其值得关注。
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