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人类细胞株对猿猴病毒40及猿猴病毒40脱氧核糖核酸转化的敏感性。

Susceptibility of human cell strains to transformation by simian virus 40 and simian virus 40 deoxyribonucleic acid.

作者信息

Aaronson S A

出版信息

J Virol. 1970 Oct;6(4):470-5. doi: 10.1128/JVI.6.4.470-475.1970.

DOI:10.1128/JVI.6.4.470-475.1970
PMID:5497893
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC376145/
Abstract

Marked differences were found in the susceptibility of human fibroblasts to transformation by simian virus 40 (SV40). Highly susceptible cell strains were derived from patients with diseases associated with chromosomal abnormalities and a high incidence of tumors. In the present study, SV40 transformation-susceptible cell strains were not found to have a generalized increase in viral sensitivity. The differences in transformation frequency among cell strains with whole virus are eliminated by the use of isolated SV40 deoxyribonucleic acid, suggesting that the relative resistance of most cell strains to transformation by whole virus is due to a block at an early step in infection.

摘要

在人成纤维细胞对猿猴病毒40（SV40）转化的易感性方面发现了显著差异。高度易感细胞株源自患有与染色体异常和高肿瘤发病率相关疾病的患者。在本研究中，未发现对SV40转化易感的细胞株普遍提高了病毒敏感性。使用分离的SV40脱氧核糖核酸可消除全病毒处理的细胞株间转化频率的差异，这表明大多数细胞株对全病毒转化的相对抗性是由于感染早期的一个阻断步骤所致。

相似文献

1
Susceptibility of human cell strains to transformation by simian virus 40 and simian virus 40 deoxyribonucleic acid.人类细胞株对猿猴病毒40及猿猴病毒40脱氧核糖核酸转化的敏感性。
J Virol. 1970 Oct;6(4):470-5. doi: 10.1128/JVI.6.4.470-475.1970.
2
Properties of simian virus 40 rescued from cell lines transformed by ultraviolet-irradiated simian virus 40.从经紫外线照射的猴病毒40转化的细胞系中拯救出的猴病毒40的特性。
J Virol. 1969 Nov;4(5):585-95. doi: 10.1128/JVI.4.5.585-595.1969.
3
Response of simian virus 40-transformed cell lines and cell hybrids to superinfection with simian virus 40 and its deoxyribonucleic acid.猿猴病毒40转化细胞系和细胞杂种对猿猴病毒40及其脱氧核糖核酸重叠感染的反应。
J Virol. 1969 Oct;4(4):348-55. doi: 10.1128/JVI.4.4.348-355.1969.
4
Susceptibility of human diploid fibroblast strains to transformation by SV40 virus.人类二倍体成纤维细胞株对SV40病毒转化的易感性。
Science. 1966 Sep 9;153(3741):1252-4. doi: 10.1126/science.153.3741.1252.
5
Identification of the simian virus 40 which replicates when simian virus 40-transformed human cells are fused with simian virus 40-transformed mouse cells or superinfected with simian virus 40 deoxyribonucleic acid.当猿猴病毒40转化的人类细胞与猿猴病毒40转化的小鼠细胞融合或被猿猴病毒40脱氧核糖核酸超感染时，对复制的猿猴病毒40的鉴定。
J Virol. 1970 Jul;6(1):69-77. doi: 10.1128/JVI.6.1.69-77.1970.
6
Sensitivity of simian virus 40-transformed C57BL/6 mouse embryo fibroblasts to lysis by murine natural killer cells.猿猴病毒40转化的C57BL/6小鼠胚胎成纤维细胞对鼠自然杀伤细胞裂解的敏感性。
J Immunol. 1987 Feb 15;138(4):1215-20.
7
Simian virus 40 deoxyribonucleic acid replication. I. Effect of cycloheximide on the replication of SV40 deoxyribonucleic acid in monkey kidney cells and in heterokaryons of SV40-transformed and susceptible cells.猴病毒40型脱氧核糖核酸复制。I. 环己酰亚胺对猴肾细胞以及猴病毒40型转化细胞与易感细胞的异核体中猴病毒40型脱氧核糖核酸复制的影响。
J Virol. 1969 Jan;3(1):25-32. doi: 10.1128/JVI.3.1.25-32.1969.
8
Virus-specific deoxyribonucleic acid in simian virus 40-exposed hamster cells: correlation with S and T antigens.感染猿猴病毒40的仓鼠细胞中的病毒特异性脱氧核糖核酸：与S抗原和T抗原的相关性
J Virol. 1970 Aug;6(2):199-207. doi: 10.1128/JVI.6.2.199-207.1970.
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The detection of simian virus 40 in human tumors by polymerase chain reaction.
Monaldi Arch Chest Dis. 1998 Apr;53(2):202-10.
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Spontaneous virus production by clonal lines of siminan virus 40-transformed cells and effects of superinfection by deoxyribonucleic acid from mutant simian virus 40 strains.猿猴病毒40转化细胞的克隆系自发产生病毒以及突变猿猴病毒40株的脱氧核糖核酸超感染的影响。
J Virol. 1971 Oct;8(4):430-6. doi: 10.1128/JVI.8.4.430-436.1971.

引用本文的文献

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Ultrastructural and biological characterization of human choroid cell cultures transformed by Simian Virus 40.经猴病毒40转化的人脉络膜细胞培养物的超微结构和生物学特性
In Vitro. 1983 Jun;19(6):443-52. doi: 10.1007/BF02619591.
2
Replication of simian virus 40 DNA in normal human fibroblasts and in fibroblasts from xeroderma pigmentosum.猴病毒40 DNA在正常人成纤维细胞和着色性干皮病患者成纤维细胞中的复制。
J Virol. 1981 Aug;39(2):481-9. doi: 10.1128/JVI.39.2.481-489.1981.
3
Human cell transformation by simian virus 40--a review.猿猴病毒40对人类细胞的转化——综述
In Vitro. 1981 Jan;17(1):1-19. doi: 10.1007/BF02618025.
4
Characterization of morphologic revertants of murine and avian sarcoma virus-transformed cells.鼠源和禽源肉瘤病毒转化细胞的形态学回复突变体的特性分析。
J Virol. 1973 Feb;11(2):218-22. doi: 10.1128/JVI.11.2.218-222.1973.
5
Genetic analysis of simian virus 40. 3. Characterization of a temperature-sensitive mutant blocked at an early stage of productive infection in monkey cells.猴病毒40的遗传分析。3. 一种在猴细胞生产性感染早期受阻的温度敏感突变体的特性。
J Virol. 1972 Jun;9(6):956-68. doi: 10.1128/JVI.9.6.956-968.1972.
6
Transformation of sheep cells by simian virus 40.猴病毒40对绵羊细胞的转化
Arch Gesamte Virusforsch. 1972;37(1):71-7. doi: 10.1007/BF01241152.
7
Studies of nondefective adenovirus 2-simian virus 40 hybrid viruses. IV. Characterization of the simian virus 40 ribonucleic acid species induced by wild-type simian virus 40 and by the nondefective hybrid virus, Ad2 + ND 1 .非缺陷型腺病毒2-猴病毒40杂交病毒的研究。IV. 野生型猴病毒40和非缺陷型杂交病毒Ad2+ND1诱导的猴病毒40核糖核酸种类的特性
J Virol. 1971 Aug;8(2):215-24. doi: 10.1128/JVI.8.2.215-224.1971.
8
Immortalization of human fibroblasts transformed by origin-defective simian virus 40.由原点缺陷型猿猴病毒40转化的人成纤维细胞的永生化
Mol Cell Biol. 1987 Aug;7(8):2794-802. doi: 10.1128/mcb.7.8.2794-2802.1987.
9
Carcinogenesis in vitro. II. Chemical transformation of diploid human cell cultures: A rare event.体外致癌作用。II. 二倍体人类细胞培养物的化学转化：一个罕见事件。
In Vitro. 1975 May-Jun;11(3):117-29. doi: 10.1007/BF02615420.
10
Some aspects of the role of viruses in cancer.病毒在癌症中作用的某些方面。
Postgrad Med J. 1979 Feb;55(640):150-8. doi: 10.1136/pgmj.55.640.150.

本文引用的文献

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DETECTION OF SPECIFIC ANTIGEN IN SV40-TRANSFORMED CELLS BY IMMUNOFLUORESCENCE.免疫荧光法检测SV40转化细胞中的特异性抗原
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Human diploid cell transformation by DNA extracted from the tumor virus SV40.用从肿瘤病毒SV40中提取的DNA对人二倍体细胞进行转化。
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Variable susceptibility of human cell strains to SV40 transformation.
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SV40 T antigen induction and transformation in human fibroblast cell strains.人成纤维细胞株中的SV40 T抗原诱导与转化
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Enchancement of the infectivity of simian virus 40 deoxyribonucleic acid with diethylaminoethyl-dextran.用二乙氨基乙基葡聚糖增强猿猴病毒40脱氧核糖核酸的感染性。
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Biophysical evidence for linkage of adenovirus and SV40 DNA's in adenovirus 7-SV40 hybrid particles.腺病毒7-SV40杂交颗粒中腺病毒与SV40 DNA连接的生物物理证据。
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